Microrobots for Biomedicine: Unsolved Challenges and Opportunities for Translation
Microrobots for Biomedicine: Unsolved Challenges and Opportunities for Translation
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DOI：
10.1021/acsnano.3c03723
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发表时间：
2023-07-26
期刊：
影响因子：
17.1
通讯作者：
Shields, C. Wyatt
中科院分区：
文献类型：
--
作者：
Lee, Jin Gyun;Raj, Ritu R.;Shields, C. Wyatt
微型机器人正被探索用于生物医学应用，如药物输送、生物货物运输和微创手术。然而，目前的努力主要集中在通过“设计和应用”方法使用不可翻译材料的概念验证研究上，限制了临床适应的潜力。虽然这些概念验证研究是推进微型机器人技术的关键，但我们相信，通过“按问题设计”方法，微型机器人的独特功能将最容易被带到患者床边，which哪一个involves涉及focusingon未solved解决problems问题to inform通知design设计of microrobots微型robots机器人with practicalcapabilities能力.如下文所述，我们建议通过明智地选择目标应用、改进递送考虑以及合理选择可用于预防的生物材料来加速微型机器人的临床预防，最终减轻患者负担并提高治疗药物对难治性疾病的疗效。
Microrobots are being explored for biomedical applications,suchas drug delivery, biological cargo transport, and minimally invasivesurgery. However, current efforts largely focus on proof-of-conceptstudies with nontranslatable materials through a "design-and-apply" approach, limiting the potential for clinical adaptation.While these proof-of-concept studies have been key to advancing microrobottechnologies, we believe that the distinguishing capabilities of microrobotswill be most readily brought to patient bedsides through a "design-by-problem" approach, which involves focusingon unsolved problems to inform the design of microrobots with practicalcapabilities. As outlined below, we propose that the clinical translationof microrobots will be accelerated by a judicious choice of targetapplications, improved delivery considerations, and the rational selectionof translation-ready biomaterials, ultimately reducing patient burdenand enhancing the efficacy of therapeutic drugs for difficult-to-treatdiseases.