Antidiabetic effects of quercetin in streptozocin-induced diabetic rats
Antidiabetic effects of quercetin in streptozocin-induced diabetic rats
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DOI：
10.1016/s1532-0456(03)00140-6
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发表时间：
2003-07-01
影响因子：
3.9
通讯作者：
Vasei, M
中科院分区：
文献类型：
--
作者：
Vessal, M;Hernmati, M;Vasei, M
观察槲皮素腹腔注射对链脲佐菌素诱导的糖尿病大鼠和正常大鼠的影响。槲皮素对正常动物的血糖水平无影响，但能显著降低链脲佐菌素诱导的糖尿病大鼠的血糖水平，并呈剂量依赖性。糖尿病动物的糖耐量试验接近正常大鼠，其血浆胆固醇和甘油三酯显着降低，而其肝葡萄糖激酶活性显着增加槲皮素治疗。在正常大鼠中，槲皮素不影响葡萄糖耐量试验，但导致血浆胆固醇和甘油三酯的增加和肝葡萄糖激酶活性的降低。在肝细胞或肾小管和肾小球中未观察到显著的病理变化。而正常组和糖尿病组的胰岛数量均显著增加。结论：槲皮素是一种具有抗氧化作用的黄酮类化合物，可促进胰岛再生，并可能增加链脲佐菌素诱导的糖尿病大鼠胰岛素的释放，从而发挥其有益的抗糖尿病作用。然而，在血糖正常的动物中可能没有什么价值。(C)2003年爱思唯尔公司All rights reserved.
Effects of the intraperitoneal injection of quercetin in streptozocin-induced diabetic and normal rats were investigated and compared. Although quercetin had no effect on plasma glucose level of normal animals, it significantly and dose-dependently decreased the plasma glucose level of streptozocin-induced diabetic rats. Glucose tolerance tests of the diabetic animals approached those of normal rats, their plasma cholesterol and triglycerides were reduced significantly, while their hepatic glucokinase activity was significantly increased upon quercetin treatment. In normal rats, quercetin did not affect the glucose tolerance test, but resulted in an increase of plasma cholesterol and triglycerides and a decrease in hepatic glucokinase activity. No significant pathologic changes were noted in hepatocytes or kidney tubules and glomeruli. while the number of pancreatic islets significantly increased in both treated normal and diabetic groups. It is concluded that quercetin, a flavonoid with antioxidant properties brings about the regeneration of the pancreatic islets and probably increases insulin release in streptozocin-induced diabetic rats; thus exerting its beneficial antidiabetic effects. However, it may be of little value in normoglycemic animals. (C) 2003 Elsevier Inc. All rights reserved.