Cigarette experimentation in Mexican origin youth: psychosocial and genetic determinants.
Cigarette experimentation in Mexican origin youth: psychosocial and genetic determinants.
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DOI：
10.1158/1055-9965.epi-11-0456
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发表时间：
2012-01
期刊：
影响因子：
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通讯作者：
Spitz MR
中科院分区：
文献类型：
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作者：
Wilkinson AV;Bondy ML;Wu X;Wang J;Dong Q;D'Amelio AM Jr;Prokhorov AV;Pu X;Yu RK;Etzel CJ;Shete S;Spitz MR
既定的心理社会风险因素增加了墨西哥裔青年中的实验风险。现在，我们全面调查选择多态性在候选基因通路与感觉寻求，冒险和吸烟表型预测实验的贡献。参与者（N= 1，118名墨西哥裔青年）从德克萨斯州休斯顿的一项大型人群队列研究中招募，提供了三年内香烟实验的前瞻性数据。社会心理数据被引出两次基线和最终随访。参与者在多巴胺，5-羟色胺和阿片途径中对672种功能和标记变体进行基因分型。在调整性别和年龄后，贝叶斯错误发现概率设置为0.8，先验概率为0.05，六个基因变异与实验风险显著相关。在控制了已建立的风险因素后，多变量分析显示，具有6个或更多风险等位基因的参与者自基线以来进行实验的可能性是具有5个或更少风险等位基因的参与者的2.25倍（95%CI：1.62-3.13）。在从不吸烟的人（N=872）中，三个基因（OPRM 1，SNAP 25，HTR 1B）与实验相关，所有心理社会因素也是如此。在易感青年（N=246）中，基线年龄较大，与吸烟者生活在一起，三种不同的基因（HTR 2A，DRD 2，SLC 6A 3）预测实验。我们的研究结果，这对特定文化的干预措施的发展有影响，需要在其他种族群体进行验证。这些结果表明，选择基因的变异与吸烟的认知倾向相互作用。在易感青少年中，遗传变异的影响似乎比承诺从不吸烟者更大。
Established psychosocial risk factors increase the risk for experimentation among Mexican-origin youth. Now we comprehensively investigate the added contribution of select polymorphisms in candidate genetic pathways associated with sensation seeking, risk taking, and smoking phenotypes to predict experimentation. Participants, (N=1,118 Mexican origin youth) recruited from a large population-based cohort study in Houston, Texas, provided prospective data on cigarette experimentation over three years. Psychosocial data were elicited twice—baseline and final follow-up. Participants were genotyped for 672 functional and tagging variants in the dopamine, serotonin and opioid pathways. After adjusting for gender and age, with a Bayesian False Discovery Probability set at 0.8 and prior probability of 0.05, six gene variants were significantly associated with risk of experimentation. After controlling for established risk factors, multivariable analyses revealed that participants with six or more risk alleles were 2.25 (95%CI: 1.62–3.13) times more likely to have experimented since baseline compared to participants with five or fewer. Among committed never smokers (N=872), three genes (OPRM1, SNAP25, HTR1B) were associated with experimentation as were all psychosocial factors. Among susceptible youth (N=246) older age at baseline, living with a smoker, and three different genes (HTR2A, DRD2, SLC6A3) predicted experimentation. Our findings, which have implications for development of culturally-specific interventions, need to be validated in other ethnic groups. These results suggest that variations in select genes interact with a cognitive predisposition toward smoking. In susceptible adolescents, the impact of the genetic variants appears to be larger compared to committed never smokers.