The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
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DOI：
10.1016/s1074-7613(00)80065-5
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发表时间：
1999-06-01
期刊：
影响因子：
32.4
通讯作者：
Baltimore, D
中科院分区：
文献类型：
--
作者：
Cohen, GB;Gandhi, RT;Baltimore, D
为了避免被CTL检测到，HIV编码从感染细胞表面去除I类MHC蛋白的机制。然而，I类下调可能使病毒感染的细胞暴露于NK细胞的攻击。人类淋巴细胞主要通过HLA-C和HLA-E来保护免受NK细胞的细胞毒性。我们提出的证据表明，HIV-1选择性地下调HLA-A和HLA-B，但不显著影响HLA-C或HLA-E。然后，我们鉴定了HLA-C和HLA-E中保护它们免受艾滋病毒下调的残基。这种选择性下调允许HIV感染的细胞避免NK细胞介导的裂解，并且可能代表HIV逃避CTL和维持对NK细胞的保护之间的平衡。这些结果表明，CTL和NK细胞的亚群可能是唯一适合于对抗艾滋病毒。
To avoid detection by CTL, HIV encodes mechanisms for removal of class I MHC proteins from the surface of infected cells. However, class I downregulation potentially exposes the virus-infected cell to attack by NK cells. Human lymphoid cells are protected from NK cell cytotoxicity primarily by HLA-C and HLA-E, We present evidence that HIV-1 selectively downregulates HLA-A and HLA-B but does not significantly affect HLA-C or HLA-E. We then identify the residues in HLA-C and HLA-E that protect them from HIV downregulation. This selective downregulation allows HIV-infected cells to avoid NK cell-mediated lysis and may represent for HIV a balance between escape from CTL and maintenance of protection from NK cells. These results suggest that subpopulations of CTL and NK cells may be uniquely suited for combating HIV.