Prognostic Significance of 18F-FDG PET/CT Metabolic Parameters and Tumor Galectin-1 Expression in Patients With Surgically Resected Lung Adenocarcinoma
Prognostic Significance of 18F-FDG PET/CT Metabolic Parameters and Tumor Galectin-1 Expression in Patients With Surgically Resected Lung Adenocarcinoma
复制标题
18F-FDG PET/CT 代谢参数和肿瘤 Galectin-1 表达在手术切除的肺腺癌患者中的预后意义
DOI：
10.1016/j.cllc.2019.04.002
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发表时间：
2019-11-01
影响因子：
3.6
通讯作者：
Li, Yaming
中科院分区：
文献类型：
--
作者：
Zheng, Hongna;Cui, Yan;Li, Yaming
Galectin-1（Gal-1）是一种促进免疫抑制和癌症发展的调节检查点。我们通过免疫组化检测了Gal-1的表达，发现手术切除的肺腺癌患者Gal-1表达与正电子发射断层扫描/计算机断层扫描（PET/CT）代谢参数之间存在显著正相关。目的：探讨肺腺癌患者手术前后F-18-FDG（F-18-fluorodeoxyglucose，F-18-FDG）正电子发射断层扫描（positron emission tomography，PET）/计算机断层扫描（computed tomography，CT）代谢参数和肿瘤半乳糖凝集素-1（tumor galectin-1，Gal-1）表达的变化及其与预后的关系。患者和方法：方法回顾性分析96例经F-18-FDG PET/CT证实的原发性肺腺癌患者的临床资料。通过PET/CT成像测量原发肿瘤的最大标准化摄取值（SUVmax）、代谢肿瘤体积和总病变糖酵解。免疫组化法检测Gal-1、葡萄糖转运蛋白1（GLUT-1）和己糖激酶II（HK-II）的表达。结果如下：肿瘤Gal-1和SUVmax、肿瘤Gal-1和代谢肿瘤体积、肿瘤Gal-1和总病变糖酵解、肿瘤Gal-1和GLUT-1表达、肿瘤Gal-1和HK-II表达以及SUVmax和肿瘤GLUT-1和HK-II表达之间存在显著正相关（所有病例中P < .0001）。SUVmax是肿瘤Gal-1表达的唯一独立预测因子。在受试者工作特征分析中，SUVmax预测肿瘤Gal-1表达的最佳截止值为5.1。Gal-1阳性肿瘤患者的无进展生存期和总生存期明显短于Gal-1阴性肿瘤患者（P
Galectin-1 (Gal-1) is a regulatory checkpoint that promotes immunosuppression and cancer development. We examined Gal-1 expression through immunohistochemistry and found that there was a significant positive correlation between Gal-1 expression and positron emission tomography/computed tomography (PET/CT) metabolic parameters in patients with surgically resected lung adenocarcinoma. Our results highlight PET/CT can predict Gal-1 expression and prognosis in lung adenocarcinoma.Purpose: To study the prognostic significance of F-18-fluorodeoxyglucose (F-18-FDG) positron emission tomography (PET)/computed tomography (CT) metabolic parameters and tumor galectin-1 (Gal-1) expression in patients surgically treated for lung adenocarcinoma. Patients and Methods: The medical records of 96 patients with primary lung adenocarcinoma who underwent surgery after F-18-FDG PET/CT were retrospectively reviewed. The maximal standardized uptake value (SUVmax), metabolic tumor volume, and total lesion glycolysis of the primary tumor were measured through PET/CT imaging. The expression of tumor Gal-1, glucose transporter 1 (GLUT-1), and hexokinase II (HK-II) were examined through immunohistochemistry. Results: There were significant positive correlations between tumor Gal-1 and SUVmax, tumor Gal-1 and metabolic tumor volume, tumor Gal-1 and total lesion glycolysis, tumor Gal-1 and GLUT-1 expression, tumor Gal-1 and HK-II expression, and SUVmax and tumor GLUT-1 and HK-II expression (P < .0001 in all cases). SUVmax was the only independent predictor of tumor Gal-1 expression. On receiver operating characteristic analysis, the optimal cutoff value of SUVmax for predicting tumor Gal-1 expression was 5.1. Progression-free and overall survival were significantly shorter in patients with Gal-1-positive tumors than in those with Gal-1-negative tumors (P