Clinical trial of Cecropia obtusifolia and Marrubium vulgare leaf extracts on blood glucose and serum lipids in type 2 diabetics
Clinical trial of Cecropia obtusifolia and Marrubium vulgare leaf extracts on blood glucose and serum lipids in type 2 diabetics
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DOI：
10.1016/j.phymed.2004.01.006
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发表时间：
2004-11-01
期刊：
影响因子：
7.9
通讯作者：
Tortoriello, J
中科院分区：
文献类型：
--
作者：
Herrera-Arellano, A;Aguilar-Santamaría, L;Tortoriello, J
Cecropia obtusifolia和Marrubium vulgare在墨西哥传统医学中被广泛用于控制2型糖尿病。为了评价这些物种的水提取物对2型未控制糖尿病的临床效果，共纳入43名门诊患者。根据欧洲NIDDM（政策组）标准，仅选择对常规治疗反应差的患者。所有患者都保持了药物治疗，并接受了21天的植物治疗干叶的准备输液。以双盲方式，患者随机分组如下：22例患者接受钝叶升麻治疗，21例患者接受M。粗俗。C obtusifolia治疗组空腹血糖值降低了15.25%，而胆固醇和甘油三酯分别降低了14.62%和42.0%（ANOVA p < 0.02）。在用M.普通的，血浆葡萄糖水平降低0.64%，胆固醇和甘油三酯分别降低4.16%和5.78%。当比较两组的结果时，结果表明，用钝叶升麻叶制备的浸液，（每克干植物含2.99 +/- 0.14毫克绿原酸）当它作为2型糖尿病患者的辅助治疗时，对常规治疗的反应。(C)2004年Elsevier GmbH。All rights reserved.
Cecropia obtusifolia and Marrubium vulgare have been widely used in Mexican traditional medicine for the control of type 2 diabetes. In order to evaluate the clinical effect produced by the aqueous extract from these species on type 2 non-controlled diabetes mellitus, a total of 43 outpatients were included. Based on the European NIDDM (policy group) criteria, only patients with poor response to the conventional treatment were selected. All patients maintained their medical treatment and also received a prepared infusion of the dry leaves of the plant treatment for 21 days. In a double-blind manner, the patients were randomly grouped as follows: 22 patients were treated with C obtusifolia and 21 with M. vulgare. The fasting blood glucose values were reduced by 15.25% on patients treated with C obtusifolia, while cholesterol and triglycerides were decreased by 14.62% and 42.0%, respectively (ANOVA p < 0.02). In the case of patients treated with M. vulgare, the plasma glucose level was reduced by 0.64% and cholesterol and triglycerides by 4.16% and 5.78%, respectively. When the results were compared between groups, significant differences in glucose and cholesterol diminution were found. The obtained results showed that the infusion prepared with the leaves of C obtusifolia (containing 2.99 +/- 0.14 mg of chlorogenic acid/g of dried plant) produced beneficial effects on carbohydrate and lipid metabolisms when it was administered as an adjunct on patients with type 2 diabetes with poor response to conventional medical treatment. (C) 2004 Elsevier GmbH. All rights reserved.