Identification of Alzheimer disease risk by functional magnetic resonance imaging
Identification of Alzheimer disease risk by functional magnetic resonance imaging
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DOI：
10.1001/archneur.62.12.1881
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发表时间：
2005-12-01
影响因子：
--
通讯作者：
Bondi, MW
中科院分区：
文献类型：
--
作者：
Fleisher, AS;Houston, WS;Bondi, MW
背景：功能性磁共振成像在阿尔茨海默病 (AD) 的临床前表征方面发挥着重要作用，可用于早期诊断和预防性药物试验。目的：确定功能性磁共振成像是否能够可靠地区分认知正常中年成年人中 AD 的危险人群。设计：横断面病例对照研究背景：加州大学圣地亚哥分校阿尔茨海默病研究中心参与者和圣地亚哥社区志愿者。参与者：20 名认知正常个体（10 名高风险和 10 名低风险），根据是否存在载脂蛋白 E epsilon 4 等位基因以及 AD 阳性家族史，将年龄 58 至 65 岁的受试者分为 2 组。 主要结果测量：词对以块状设计呈现，在新词对、重复词对和固定词对之间交替出现。比较不同风险组之间血氧水平依赖性大脑反应的全脑差异。结果：与低风险组相比，高风险组在通常与 AD 病理相关的区域（例如左内侧颞叶）表现出许多不同的血氧水平依赖性反应区域。此外，还证明了左内侧颞叶活动与记忆表现之间存在不同的关联模式。结论：结果支持了一种理论，即在典型发病年龄之前许多年，有 AD 风险的人群的神经元记忆系统上调。他们进一步证明，功能性磁共振成像是识别 AD 风险人群的可行技术。
Background: Functional magnetic resonance imaging plays a promising role in the preclinical characterization of Alzheimer disease (AD) for use in early diagnosis and in preventive drug trials.Objective: To determine whether functional magnetic resonance imaging can reliably distinguish risk groups for AD among cognitively normal middle-aged adults.Design: Cross-sectional case-control studySetting: University of California, San Diego, Alzheimer Disease Research Center participants and San Diego community volunteers.Participants: Twenty cognitively normal individuals (10 high risk and 10 low risk), aged 58 to 65 years, were divided into 2 groups based on the presence or absence of the apolipoprotein E epsilon 4 allele and a positive family history of AD.Main Outcome Measures: Word pairs were presented in a blocked design alternating between conditions of novel pairs, repeated pairs, and fixation. Whole-brain differences in blood oxygenation level-dependent brain responses between conditions were compared across risk groups.Results: Compared with the low-risk group, the high-risk group showed many areas of differential blood oxygenation level-dependent response in regions commonly associated with AD pathology (eg, the left medial temporal lobe). Furthermore, different patterns of association between left medial temporal lobe activity and memory performance were demonstrated.Conclusions: Results support a theory of upregulation in neuronal memory systems in people at risk for AD many years before the typical age at disease onset. They further demonstrate that functional magnetic resonance imaging is a viable technique to identify persons at risk for AD.