Correlation of Uric Acid Levels and Parameters of Metabolic Syndrome
Correlation of Uric Acid Levels and Parameters of Metabolic Syndrome
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DOI：
10.33549/physiolres.933410
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发表时间：
2017-01-01
影响因子：
2.1
通讯作者：
Karasek, D.
中科院分区：
文献类型：
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作者：
Cibickova, L.;Langova, K.;Karasek, D.
高尿酸血症被描述为与发生代谢综合征的风险相关；然而，尿酸水平与代谢综合征特定参数之间的关系仍不清楚。我们对 833 名血脂异常患者进行了一项横断面研究，并将他们的尿酸水平与胰岛素抵抗、脂质代谢、C 反应蛋白、人体测量参数等参数相关联。我们还定义了患有高甘油三酯腰部表型的患者，并将他们的尿酸水平与没有这种表型的患者进行了比较。我们发现尿酸水平与代谢综合征的参数相关。具体而言，代谢综合征特征的血脂异常（低高密度脂蛋白胆固醇和高甘油三酯）与尿酸水平的相关性比与胰岛素抵抗参数的相关性更好。此外，与体重指数相比，腰围与尿酸水平的相关性更好。与无高甘油三酯腰部表型的患者相比，具有高甘油三酯腰部表型的患者尿酸水平较高。血清尿酸水平即使在较低水平，也与代谢综合征参数线性相关（典型的脂质特征比胰岛素抵抗参数更好），并且可能与较高的心血管风险相关。
Hyperuricemia has been described as associated with the risk of development metabolic syndrome; however the relationship between the uric acid level and particular parameters of metabolic syndrome remained unclear. We performed a cross-sectional study on a cohort of 833 dyslipidemic patients and correlated their levels of uric acid with parameters of insulin resistance, lipid metabolism, C-reactive protein, anthropometric parameters. We also defined patients with hypertriglyceridemic waist phenotype and compered their uric acid levels with those without this phenotype. We found that levels of uric acid are associated with parameters of metabolic syndrome. Specifically, dyslipidemia characteristic for metabolic syndrome (low HDL cholesterol and high triglycerides) correlates better with uric acid levels than parameters of insulin resistance. Also waist circumference correlates better with uric acid levels than body mass index. Patients with hypertriglyceridemic waist phenotype had higher levels of uric acid when compared with patients without this phenotype. Serum uric acid levels are even in low levels linearly correlated with parameters of metabolic syndrome (better with typical lipid characteristics than with parameters of insulin resistance) and could be associated with higher cardiovascular risk.