Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas.
Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas.
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发表时间：
1998-09
期刊：
影响因子：
11.2
通讯作者：
T. Hida;Y. Yatabe;H. Achiwa;H. Muramatsu;K. Kozaki;S. Nakamura;M. Ogawa;T. Mitsudomi;T. Sugiura
中科院分区：
文献类型：
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作者：
T. Hida;Y. Yatabe;H. Achiwa;H. Muramatsu;K. Kozaki;S. Nakamura;M. Ogawa;T. Mitsudomi;T. Sugiura
应用免疫组织化学方法检测了59例肺癌组织、正常肺组织及癌前病变肺组织中环氧合酶（考克斯）-2的表达。与正常外周气道上皮细胞中可见的散在弱反应性相反，在约三分之一的非典型腺瘤性增生和原位癌标本中检测到考克斯-2表达显著上调，并且在70%的浸润性腺癌病例中观察到考克斯-2表达显著增加。有趣的是，淋巴结转移瘤中考克斯-2表达显著的腺癌细胞比例远高于相应的原发肿瘤。相比之下，小细胞癌显示几乎可以忽略不计的表达，鳞状细胞癌显示罕见和低表达。这些发现表明，考克斯-2表达的增加可能与腺癌的发展有关，并可能与侵袭性和转移性表型的获得有关。
Cyclooxygenase (COX)-2 expression was immunohistochemically examined in 59 human lung cancers as well as in normal and premalignant lung specimens. In contrast to scattered weak reactivity seen in normal peripheral airway epithelial cells, markedly up-regulated COX-2 expression was detected in about one-third of atypical adenomatous hyperplasias and carcinoma in situ specimens, and a significant increase in COX-2 expression was observed in 70% of invasive adenocarcinoma cases. Interestingly, the proportion of adenocarcinoma cells with marked COX-2 expression was much greater in lymph node metastases than in the corresponding primary tumors. In contrast, small cell carcinomas showed virtually negligible expression, and squamous cell carcinomas showed infrequent and low expression. These findings suggest that an increase in COX-2 expression may be associated with the development of adenocarcinomas and possibly with acquisition of an invasive and metastatic phenotype.