Printable homocomposite hydrogels with synergistically reinforced molecular-colloidal networks.
Printable homocomposite hydrogels with synergistically reinforced molecular-colloidal networks.
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DOI：
10.1038/s41467-021-23098-9
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发表时间：
2021-05-14
影响因子：
16.6
通讯作者：
Velev OD
中科院分区：
文献类型：
--
作者：
Williams AH;Roh S;Jacob AR;Stoyanov SD;Hsiao L;Velev OD
其中多个互穿网络能够增强机械性能的水凝胶的设计可以拓宽其在生物医学材料，3D打印和软机器人中的应用领域。我们报道了一类自增强的均质复合水凝胶（HHGs），由多尺度层次的互穿网络组成。分子海藻酸盐凝胶通过分级分支的海藻酸盐软树枝状胶体（SDC）的胶体网络增强。用相同生物聚合物的纳米纤维状SDC网络增强分子凝胶导致HHG的机械性能显著增加。在相同浓度下，粘弹性HHG显示出比任一本构网络大>3倍的储能模量和>4倍的杨氏模量。这种协同增强的胶体-分子HHG为具有稳健结构-性质关系的生物相容性凝胶的制剂开辟了许多机会。其前体比例的平衡有助于精确控制屈服应力和自增强速率，从而实现HHG的高效挤出3D打印。由单一聚合物组成的复合材料，但允许调节基体的机械性能而不产生应力集中，这对制造来说是具有挑战性的。在这里，作者设计了一种自增强的同质复合藻酸盐水凝胶，其机械性能增强，在基质中加入了柔软的树枝状藻酸盐胶体，并展示了其在挤出印刷中的应用。
The design of hydrogels where multiple interpenetrating networks enable enhanced mechanical properties can broaden their field of application in biomedical materials, 3D printing, and soft robotics. We report a class of self-reinforced homocomposite hydrogels (HHGs) comprised of interpenetrating networks of multiscale hierarchy. A molecular alginate gel is reinforced by a colloidal network of hierarchically branched alginate soft dendritic colloids (SDCs). The reinforcement of the molecular gel with the nanofibrillar SDC network of the same biopolymer results in a remarkable increase of the HHG’s mechanical properties. The viscoelastic HHGs show >3× larger storage modulus and >4× larger Young’s modulus than either constitutive network at the same concentration. Such synergistically enforced colloidal-molecular HHGs open up numerous opportunities for formulation of biocompatible gels with robust structure-property relationships. Balance of the ratio of their precursors facilitates precise control of the yield stress and rate of self-reinforcement, enabling efficient extrusion 3D printing of HHGs. Composites which are made up of a single polymer, and yet allow modulation of the mechanical properties of the matrix without stress concentration, are challenging to fabricate. Here, the authors design a selfreinforced homocomposite alginate hydrogel with enhanced mechanical properties incorporating soft dendritic alginate colloids in the matrix and demonstrate its application in extrusion printing.
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