Optimized glutamate detection at 3T.
Optimized glutamate detection at 3T.
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DOI：
10.1002/jmri.21936
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发表时间：
2009-11
影响因子：
4.4
通讯作者：
Hancu, Ileana
中科院分区：
文献类型：
--
作者：
Hancu, Ileana
识别脉冲序列和采集参数，从而最准确和可重复地测量3T时大脑中的谷氨酸(Glu)浓度。进行模拟以比较四个一般类别(PRESS、STEAM、CAR-PERCEL PRESS(CPRESS)和TE Average PRESS(JPRESS))中11个脉冲序列和采集参数的准确性和重复性，其中大多数先前被认为是最适合Glu检测的。其中三个模拟采集在临床扫描仪中实施，体内重复性的测量与它们的模拟值进行了比较。模拟和实验确定的重复性测量之间有很好的一致性。在考虑的采集中，具有最小回声时间的CPRESS序列，以及可能的短TE PRESS序列，导致最可重复的Glu测量，同时略微高估了Glu浓度。JPRESS序列的模拟证明了极好的准确性，但代价是重复性低于最佳PRESS或CPRESS序列。进一步的概念证明是为了验证一种模拟方法，以了解脉冲序列在测量给定代谢物浓度时的性能。对CPRESS改进的Glu测量重复性进行了预测和验证。
To identify the pulse sequence and acquisition parameters that result in the most accurate and repeatable measurements of glutamate (Glu) concentration in the brain at 3T. Simulations were performed to compare the accuracy and repeatability of eleven pulse sequences and acquisition parameters, within four general classes (PRESS, STEAM, Car-Purcell PRESS (CPRESS) and TE averaged PRESS (JPRESS)), the majority of which were previously suggested as optimal for Glu detection. Three of the simulated acquisitions were implemented in a clinical scanner, and measures of repeatability in vivo were compared to their simulated values. Good agreement was demonstrated between simulated and experimentally determined measures of repeatability. Among the acquisitions considered, a CPRESS sequence with minimal echo time, together with, possibly, a short TE PRESS sequence, result in the most repeatable Glu measurements, while slightly overestimating the Glu concentration. Excellent accuracy is demonstrated by the simulations for a JPRESS sequence, at the expense of lower repeatability than optimal PRESS or CPRESS sequences. Further proof of concept is presented towards validation of a simulation approach to understand pulse sequence performance in measuring the concentration of a given metabolite. Improved Glu measurement repeatability is predicted for CPRESS and demonstrated .
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影响因子：
4.4
作者：
Träber, F;Block, W;Schild, HH
通讯作者：
Schild, HH
影响因子：
14.5
作者：
Srinivasan, R;Sailasuta, N;Pelletier, D
通讯作者：
Pelletier, D
影响因子：
3.3
作者：
Yang, Shaolin;Hu, Jiani;Yang, Yihong
通讯作者：
Yang, Yihong
影响因子：
3.3
作者：
Kanowski, M;Kaufmann, J;Tempelmann, C
通讯作者：
Tempelmann, C
DOI：
10.1006/jmra.1994.1008
发表时间：
1994-01-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES A
影响因子：
--
作者：
SMITH, SA;LEVANTE, TO;ERNST, RR
通讯作者：
ERNST, RR