Social stress does not interact with paradoxical sleep deprivation-induced memory impairment
Social stress does not interact with paradoxical sleep deprivation-induced memory impairment
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DOI：
10.1016/s0166-4328(01)00345-x
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发表时间：
2002-02-01
影响因子：
2.7
通讯作者：
Oliveira, MGM
中科院分区：
文献类型：
--
作者：
Dametto, M;Suchecki, D;Oliveira, MGM
大量的证据表明，矛盾睡眠（PS）和压力都与记忆处理有关。本研究的目的是探讨社会不稳定压力对记忆的影响，并验证这种压力是否干扰PS剥夺的遗忘效应，使用改进的多平台方法。除了PS剥夺组（放在剥夺槽内的狭窄平台上），还使用了两个对照组：其中一个保持在其家庭笼中，另一个被放置在剥夺槽内，放在一个网格上，网格上有大平台。96小时的睡眠剥夺后，立即训练动物在三个不同的记忆任务：抑制性回避，经典的恐惧条件反射离散的刺激和上下文的恐惧条件反射。训练后24小时，对动物进行测试以评估任务获取。结果表明，社会不稳定并没有损害动物的表现，也没有互动与PS剥夺在任何任务。网格控制动物提出了一个选择性的障碍，在抑制性回避任务和上下文，但不是在经典的，恐惧条件反射任务相比，笼控制大鼠。这一发现可能是由于网格对照动物在操作期间暴露于压力（湿度和光度）所致。PS剥夺的动物表现出较差的性能比其他组在所有的任务。由于它们还显示出对电击诱导的发声的阈值增加，但不显示出退缩反应的阈值增加，因此不可能完全排除对伤害性刺激的反应降低作为PS剥夺的当前结果的促成因素。(C)2002 Elsevier Science B.V.保留所有权利。
Extensive evidence has linked both paradoxical sleep (PS) and stress to memory processing. The purpose of the present study was to examine the effect of social instability stress on memory and to verify whether this stress interferes with the amnesic effect of PS deprivation using the modified multiple platform method. In addition to the PS-deprived group (put onto narrow platforms inside the deprivation tanks) two control groups were used: one of them remained in its home-cages and the other was placed inside the deprivation tanks, onto a grid that contained large platforms on it. All groups were subdivided in socially stable and unstable conditions. Immediately after 96 h of sleep deprivation, the animals were trained in three different memory tasks: inhibitory avoidance, classical fear conditioning to a discrete stimulus and contextual fear conditioning. Twenty-four hours after training, the animals were tested in order to assess task acquisition. The results showed that social instability did not impair the performance of animals nor interacted with PS deprivation in any of the tasks. Grid control animals presented a selective impairment in the inhibitory avoidance task and contextual, but not in the classical, fear conditioning task, compared to cage control rats. This finding could be due to the stress to which grid control animals were exposed (humidity and luminosity) during the manipulation period. PS-deprived animals exhibited poorer performance than the other groups in all tasks. As they also showed an increased threshold to shock-induced vocalisation, but not to flinch response, it is not possible to completely rule out a decreased response to noxious stimulation as a contributing factor for the present results with PS deprivation. (C) 2002 Elsevier Science B.V. All rights reserved.