Chemokine profile in the cerebrospinal fluid and serum of Vogt-Koyanagi-Harada disease
Chemokine profile in the cerebrospinal fluid and serum of Vogt-Koyanagi-Harada disease
复制标题
DOI：
10.1016/j.jneuroim.2004.07.014
复制
发表时间：
2005-01-01
影响因子：
3.3
通讯作者：
Itoyama, Y
中科院分区：
文献类型：
--
作者：
Miyazawa, I;Abe, T;Itoyama, Y
我们分析了四种趋化因子的浓度在脑脊液（CSF）和血清中Vogt-Koyanagi-Harada病（VKH），自身免疫性葡萄膜脑膜炎综合征对黑素细胞相关蛋白，与ELISA。CSF-CXCL 10/IP-10和CSF-CCL 17/TARC在VKH中显著升高。在大多数VKH病例和对照中，CSF-CXCL 10高于血清CXCL 10，CSF-CCL 17低于血清CCL 17。CCL 11/Eotaxin在组间无差异。VKH组CSF-CCL 2/MCP-1比值显著低于对照组。VKH的变化基本上与多发性硬化症（一种已知的Th 1优势疾病）相似。(C)2004 Elsevier B. V.保留所有权利。
We analyzed the concentrations of four chemokines in the cerebrospinal fluid (CSF) and sera in Vogt-Koyanagi-Harada disease (VKH), an autoimmune uveomeningitis syndrome against melanocyte-associated proteins, with ELISA. CSF-CXCL10/IP-10 and CSF-CCL17/TARC were significantly elevated in VKH than in controls. In the majority of VKH cases and controls, CSF-CXCL10 was higher than serum-CXCL10, and CSF-CCL17 was lower than serum-CCL17. CCL11/Eotaxin was not different between groups. CSF-CCL2/MCP-1 was significantly lower in VKH than in control. The changes in VKH were essentially similar to those in multiple sclerosis, a known Th1-dominant condition. (C) 2004 Elsevier B.V. All rights reserved.