Effect of taurine on epinephrine and digoxin induced irregularities of the dog heart.
Effect of taurine on epinephrine and digoxin induced irregularities of the dog heart.
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发表时间：
1963-03
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通讯作者：
W. Read;J. Welty
中科院分区：
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作者：
W. Read;J. Welty
进行实验以检验牛磺酸供应到心脏组织能够抑制肾上腺素和地高辛诱导的心律失常的假设。麻醉、迷走神经切断犬静脉给予2.5 mmol牛磺酸/kg体重，未改变心率或血压，对心脏无毒性。该化合物没有改变由肾上腺素药理剂量引起的心率或血压升高。静脉注射0.5 mmol牛磺酸/kg体重麻醉，迷走神经切断的狗抑制肾上腺素诱导的室性早搏的发展。结果表明，当心室组织中羟乙基磺酸的水平增加到每克干组织20 μmol以上时，产生室性异位节律所需的肾上腺素量会大大增加。静脉注射2 ~ 10 mmol牛磺酸/kg体重可使麻醉、切断迷走神经的犬停止急性地高辛诱导的心律失常，并使训练过的未麻醉犬的慢性地高辛诱导的室性期前收缩恢复至正常窦性心律。
Experiments were performed to test the hypothesis that taurine, supplied to heart tissue, is capable of depressing epinephrine and digoxin induced arrhythmias. The intravenous administration of 2.5 mmol of taurine per kg of body weight to anesthetized, vagotomized dogs did not alter the heart rate or blood pressure and exhibited no toxicity to the heart. The compound did not alter the increase in heart rate or blood pressure caused by pharmacological doses of epinephrine. The intravenous administration of 0.5 mmol of taurine per kg of body weight to anesthetized, vagotomized dogs depressed the development of epinephrine-induced ventricular premature contractions. The results showed that the amount of epinephrine required to produce ventricular ectopic rhythms is greatly increased when the level of isethionic acid in the ventricular tissue is increased above 20 µmol per gram of dry tissue. The intravenous administration of 2 to 10 mmol of taurine per kg of body weight to anesthetized, vagotomized dogs stopped acute digoxin-induced arrhythmias and, in trained unanesthetized dogs, reverted chronic digitoxin-induced ventricular premature contractions to a normal sinus rhythm.