Surface enhanced Raman correlation spectroscopy of particles in solution.
Surface enhanced Raman correlation spectroscopy of particles in solution.
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DOI：
10.1021/ac403882h
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发表时间：
2014-03-04
影响因子：
7.4
通讯作者：
Schultz, Zachary D.
中科院分区：
文献类型：
--
作者：
Asiala, Steven M.;Schultz, Zachary D.
表面增强拉曼相关光谱（SERCS）是一种无标记、化学特异性的方法，用于监测溶液中与二维平面表面增强拉曼（SERS）底物相互作用的单个聚合物珠和脂质囊泡。SERS基板提供的增强功能允许以31和83 Hz之间的速率串行获取频谱数据。光谱数据的自动和相互关联有助于测量半径为50至500 nm的颗粒的扩散常数，同时区分与目标分析物相关的信号和无关的波动。测量到的扩散系数约为10-10-10-11 cm2/s，比斯托克斯-爱因斯坦方程预测的要慢40倍，这表明粒子在表面的扩散受到阻碍。增强信号似乎来自SERS衬底小于5 nm的颗粒，与表面吸附一致。这项工作提供了一种测量和监测表面相互作用的方法，并展示了平面SERS基板上溶液中SERS检测的实用性和局限性。
Surface enhanced Raman correlation spectroscopy (SERCS) is shown as a label-free, chemically specific method for monitoring individual polymer beads and lipid vesicles interacting with a 2-D planar surface enhanced Raman (SERS) substrate in solution. The enhancement afforded by the SERS substrate allows for spectral data to be acquired in series at rates between 31 and 83 Hz. Auto- and cross-correlation of spectral data facilitates the measurement of diffusion constants for particles ranging in radius from 50 to 500 nm while discriminating signal associated with the target analyte from extraneous fluctuations. The measured diffusion coefficients are on the order of 10–10–10–11 cm2/s, a factor of 40 times slower than predicted from the Stokes–Einstein equation, suggesting that particles are experiencing hindered diffusion at the surface. The enhanced signals appear to originate from particles less than 5 nm of the SERS substrate, consistent with adsorption to the surface. This work provides a means to measure and monitor surface interactions and demonstrates the utility and limits of SERS detection in solution over planar SERS substrates.
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影响因子：
56.9
作者：
Fang, Ying;Seong, Nak-Hyun;Dlott, Dana D.
通讯作者：
Dlott, Dana D.
DOI：
10.1039/c1an15432j
发表时间：
2011-11-07
期刊：
The Analyst
影响因子：
--
作者：
Asiala SM;Schultz ZD
通讯作者：
Schultz ZD
影响因子：
7.4
作者：
Negri, Pierre;Jacobs, Kevin T.;Dada, Oluwatosin O.;Schultz, Zachary D.
通讯作者：
Schultz, Zachary D.
DOI：
10.1021/la301976s
发表时间：
2012-08-14
期刊：
Langmuir : the ACS journal of surfaces and colloids
影响因子：
--
作者：
Marr JM;Li F;Petlick AR;Schafer R;Hwang CT;Chabot A;Ruggiero ST;Tanner CE;Schultz ZD
通讯作者：
Schultz ZD
影响因子：
3.3
作者：
Jiang, J;Bosnick, K;Brus, L
通讯作者：
Brus, L