Vesicular transport across the fungal cell wall.

Vesicular transport across the fungal cell wall.
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DOI:
10.1016/j.tim.2008.12.005
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发表时间:
2009-04
影响因子:
15.9
通讯作者:
Rodrigues ML
Rodrigues ML
中科院分区:
生物学1区
文献类型:
--
作者:
Casadevall A;Nosanchuk JD;Williamson P;Rodrigues ML

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最近的研究结果表明,真菌使用囊泡运输,以提供跨其细胞壁的物质。真菌囊泡与哺乳动物外泌体相似,可能来源于细胞质多泡体。囊泡运输使得大分子能够穿过细胞壁输出,并且囊泡含有脂质、蛋白质和多糖,其中许多与毒力相关。囊泡中的真菌产物的浓度可以增加它们在食物获取和/或将潜在有害物质递送到其他细胞(例如阿米巴原虫或吞噬细胞)中的效率。真菌囊泡运输的发现为基础细胞生物学和发病机制的研究开辟了许多新的途径。
Recent findings indicate that fungi use vesicular transport to deliver substances across their cell walls. Fungal vesicles are similar to mammalian exosomes and could originate from cytoplasmic multivesicular bodies. Vesicular transport enables the export of large molecules across the cell wall, and vesicles contain lipids, proteins and polysaccharides, many of which are associated with virulence. Concentration of fungal products in vesicles could increase their efficiency in food acquisition and/or delivering potentially noxious substances to other cells, such as amoebae or phagocytes. The discovery of vesicular transport in fungi opens many new avenues for investigation in basic cell biology and pathogenesis.
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