Myocardial delayed enhancement by magnetic resonance imaging in patients with muscular dystrophy
Myocardial delayed enhancement by magnetic resonance imaging in patients with muscular dystrophy
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DOI：
10.1016/j.jacc.2006.10.078
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发表时间：
2007-05-08
影响因子：
24
通讯作者：
Rochitte, Carlos Eduardo
中科院分区：
文献类型：
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作者：
Silva, Marly Conceicao;Meira, Zilda Maria Alves;Rochitte, Carlos Eduardo
这项研究试图分析心血管磁共振(CMR)能否在肌营养不良症(MD)的心肌病的早期阶段检测和量化心肌损害。肌营养不良症是一种遗传性疾病，累及人类的骨骼和心脏组织。心肌病很常见，继发于心脏或呼吸系统疾病的死亡发生在生命早期。心血管磁共振是评估整体和局部心功能的可靠方法，还可以检测心肌纤维化(MF)。对10例Duchenne或Becker营养不良患者进行了CMR检查。所有患者均进行了体格检查、恰加斯病血清学检查、心电图、胸片、总肌酸激酶和多普勒超声心动图检查。有MF患者的射血分数低于无MF患者。10例患者中有7例有心肌纤维化(中壁和/或心外膜下)，其中侧壁是最常见的受累节段。节段性MF与功能障碍之间存在中度相关性。心血管磁共振可以识别MF，可能有助于检测MD心肌病的早期阶段。未来还需要评估CMR是否会影响心肌病和预后。(J Am Coll心脏ol 2007；49：1874-9)(C)2007，由美国心脏病学会基金会主办。
This study sought to analyze whether cardiovascular magnetic resonance (CMR) can detect and quantify myocardial damage in the early stages of cardiomyopathy in muscular dystrophies (MD). Muscular dystrophy is a genetic disease that involves skeletal and cardiac tissues of humans. Cardiomyopathy is common, and death secondary to cardiac or respiratory diseases occurs early in life. Cardiovascular magnetic resonance is a reliable method for assessing global and regional cardiac function, allowing also for the detection of myocardial fibrosis (MF). Ten patients with Duchenne or Becker dystrophies were studied by CMR. Physical examination, Chagas disease serological tests, electrocardiogram, chest radiograph, total creatine kinase, and Doppler echocardiogram were also obtained in all patients. Patients with MF had a lower ejection fraction than those without. Myocardial fibrosis (midwall and/or subepicardial) was observed in 7 of the 10 patients, and the lateral wall was the most commonly involved segment. There was moderate correlation between segmental MF and dysfunction. Cardiovascular magnetic resonance can identify MF and may be useful for detecting the early stages of cardiomyopathy in MD. Future work will be needed to evaluate whether CMR can influence cardiomyopathy and outcomes. (J Am Coll Cardiol 2007;49:1874-9) (C) 2007 by the American College of Cardiology Foundation.