VITAMIN-D DEFICIENCY INHIBITS PANCREATIC-SECRETION OF INSULIN
VITAMIN-D DEFICIENCY INHIBITS PANCREATIC-SECRETION OF INSULIN
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DOI：
10.1126/science.6250216
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发表时间：
1980-01-01
期刊：
影响因子：
56.9
通讯作者：
GRODSKY, GM
中科院分区：
文献类型：
--
作者：
NORMAN, AW;FRANKEL, BJ;GRODSKY, GM
维生素D缺乏对胰岛素和胰高血糖素释放的影响，测定在离体灌注大鼠胰腺分泌蛋白的放射免疫测定。在30分钟的葡萄糖和精氨酸灌注期间，与补充维生素D的维生素D缺乏大鼠的胰腺相比，维生素D缺乏大鼠的胰腺显示出48%的胰岛素分泌减少。维生素D状态对胰高血糖素分泌无影响。该结果，沿着先前证实的在胰腺中存在维生素D依赖性钙结合蛋白和维生素D的激素形式1，25-二羟基维生素D3的胞质溶胶受体，表明维生素D在胰腺的内分泌功能中的重要作用。
The effect of a vitamin D deficiency on insulin and glucagon release was determined in the isolated perfused rat pancreas by radioimmunoassay of the secreted proteins. During a 30-minute period of perfusion with glucose and arginine, pancreases from vitamin D-deficient rats exhibited a 48 percent reduction in insulin secretion compared to that for pancreases from vitamin D-deficient rats that had been replenished with vitamin D. Vitamin D status had no effect on pancreatic glucagon secretion. This result, along with the previously demonstrated presence in the pancreas of a vitamin D-dependent calcium-binding protein and cytosol receptor for the hormonal form of vitamin D, 1,25-dihydroxyvitamin D3, indicates an important role for vitamin D in the endocrine functioning of the pancreas.