Craniobot: A computer numerical controlled robot for cranial microsurgeries
Craniobot: A computer numerical controlled robot for cranial microsurgeries
复制标题
DOI：
10.1038/s41598-018-37073-w
复制
发表时间：
2019-01-31
影响因子：
4.6
通讯作者：
Kodandaramaiah, Suhasa B.
中科院分区：
文献类型：
--
作者：
Ghanbari, Leila;Rynes, Mathew L.;Kodandaramaiah, Suhasa B.
在过去的几十年里，为神经科学家开发了大量的工具来与大脑进行交互。实施这些工具需要精确地移除头骨的部分以进入大脑。这些精细的颅骨显微外科手术需要在不损害底层组织的情况下对亚毫米厚的骨骼进行手术，因此需要大量的训练。其中一些程序的自动化不仅可以实现更精确的显微外科手术，还可以促进先进神经技术的广泛使用。在这里，我们介绍“Craniobot”，这是一个颅骨显微手术平台，它结合了自动颅面仿形和计算机数控(NC)铣床，在小鼠身上执行各种颅骨显微手术程序。Craniobot利用低力接触传感器来描绘头骨表面的轮廓，并使用这些信息在几分钟内执行精确的碾磨操作。我们已经使用Craniobot进行了完整的头骨细化，并在背侧皮质上进行了从小到大的开颅手术。
Over the last few decades, a plethora of tools has been developed for neuroscientists to interface with the brain. Implementing these tools requires precisely removing sections of the skull to access the brain. These delicate cranial microsurgical procedures need to be performed on the sub-millimeter thick bone without damaging the underlying tissue and therefore, require significant training. Automating some of these procedures would not only enable more precise microsurgical operations, but also facilitate widespread use of advanced neurotechnologies. Here, we introduce the "Craniobot", a cranial microsurgery platform that combines automated skull surface profiling with a computer numerical controlled (CNC) milling machine to perform a variety of cranial microsurgical procedures on mice. The Craniobot utilizes a low-force contact sensor to profile the skull surface and uses this information to perform precise milling operations within minutes. We have used the Craniobot to perform intact skull thinning and open small to large craniotomies over the dorsal cortex.