Association between life events and change in depressive symptoms in Hong Kong Chinese elderly
Association between life events and change in depressive symptoms in Hong Kong Chinese elderly
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DOI：
10.1016/j.jad.2011.08.031
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发表时间：
2012-02-01
影响因子：
6.6
通讯作者：
Leung, Ping Chung
中科院分区：
文献类型：
--
作者：
Chan, Dicken;Kwok, Anthony;Leung, Ping Chung
背景：生活事件被认为是抑郁症的重要危险因素。只有少数几项前瞻性研究单独或综合研究了生活事件的影响。本研究旨在探讨生活事件与抑郁症状变化的关系。方法：采用老年抑郁量表（GDS）对2630名65岁以上的社区老年人的抑郁症状进行纵向评估。8分或更高的临界值表明有临床相关的抑郁症状。被确定为痴呆的受试者被排除。在2年随访时评估了过去一年中经历的8起生活事件。Logistic回归分析进行调整基线GDS评分和潜在的混杂因素，如社会人口，发展和社会因素，饮酒，病史和身体健康状况。结果：在男性，经验的两个事件（OR = 2.493）和三个或更多的事件（OR = 3.199）与抑郁症的风险增加。在女性中，仅在经历三次或三次以上事件时风险增加（OR = 5.558）。此外，生活事件对抑郁症状的影响在男性和女性之间存在差异。在男性中，失去宠物和严重的经济困难与抑郁症状的增加有关，但在女性中，伴侣的严重疾病或事故以及爱好的丧失与抑郁症状的增加有关。无论是好的或坏的重要事件的经验增加抑郁症的风险在both sexuals.Limitations：主要的限制是所有的科目是门诊volunteer.Conclusions：发生单一的生活事件的抑郁症的发病和多个事件有累积效应。(C)2011 Elsevier B.V.保留所有权利。
Background: Life event was regarded as an important risk factor for depression. Only a few prospective studies had examined the impact of life events individually and in combination. This study examined the relationship between life events and change in depressive symptoms.Methods: Depressive symptoms were assessed longitudinally using Geriatric Depression Scale (GDS) in 2630 community-dwelling Chinese elderly aged 65 or above. A cutoff score of 8 or higher indicated clinically relevant depressive symptoms. Subjects identified as demented were excluded. Eight life events experienced in the past year were assessed at 2 year follow up. Logistic regression analyses were performed with adjustments for baseline GDS score and potential confounders such as sociodemographic, developmental and social factors, alcohol consumption, medical history and physical health status.Results: In men, experience of two events (OR = 2.493) and three or more events (OR = 3.199) was independently associated with increased risk of having depression. In women, the risk increased only in experiencing three or more events (OR = 5.558). Moreover, life event affected depressive symptoms differently for men and women. Loss of pet and serious financial trouble were associated with an increase in depressive symptoms among men, but serious illness or accident of partner, and loss of a hobby were significant among women. Experience in either good or bad important events increased risk of depression in both sexes.Limitations: The main limitation was all subjects were ambulatory volunteers.Conclusions: The occurrence of single life event had contributed to the onset of depression and multiple events had a cumulative effect. (C) 2011 Elsevier B.V. All rights reserved.