Pick's disease versus Alzheimer's disease
Pick's disease versus Alzheimer's disease
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皮克病与阿尔茨海默病
作者：
M. Mendez;Allison Selwood;A. Mastri;William H Frey II
皮克病的临床识别取决于其与阿尔茨海默病（AD）的鉴别。为了识别不同的临床特征，我们回顾了21例经病理证实的皮克病患者的临床记录，并将其与42例经病理证实的AD患者的性别、发病年龄和痴呆持续时间相匹配。在CT上没有颞叶或额叶萎缩的情况下，所有Pick患者和AD患者都没有五种临床特征中的三种：老年前期发作（66岁之前），最初的性格改变，口功能亢进，去抑制和漫游行为。此外，Pick患者有口吃和其他言语障碍的倾向。这些结果表明，Pick患者可能与AD患者的临床表现的基础上区分。
The clinical recognition of Pick's disease depends on its differentiation from Alzheimer's disease (AD). To identify distinguishing clinical features, we reviewed the clinical records of 21 patients with pathologically confirmed Pick's disease and matched them by sex, age of onset, and duration of dementia with 42 patients having pathologically confirmed AD. In the absence of temporal or frontal lobar atrophy on CTs, all the Pick patients and none of the AD patients had three of five clinical features: presenile onset (before age 66), an initial personality change, hyperorality, disinhibition, and roaming behavior. In addition, the Pick patients had a tendency toward reiterative and other speech disturbances. These findings suggest that Pick patients are potentially distinguishable from AD patients on the basis of clinical manifestations.