Precisely localized LTD in the neocortex revealed by infrared-guided laser stimulation
Precisely localized LTD in the neocortex revealed by infrared-guided laser stimulation
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DOI：
10.1126/science.286.5437.110
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发表时间：
1999-10-01
期刊：
影响因子：
56.9
通讯作者：
Zieglg채nsberger, W
中科院分区：
文献类型：
--
作者：
Dodt, HU;Eder, M;Zieglg채nsberger, W
为了直接阐明长期抑郁（LTD）的起源，我们将谷氨酸应用于大鼠新皮质切片的神经元树突上。采用红外引导激光刺激，在紫外激光聚焦光斑下释放笼中的谷氨酸。一束闪光导致谷氨酸受体的反应出现类似ltd的抑制，这种抑制高度局限于“强直性”刺激区域(
In a direct approach to elucidate the origin of long-term depression (LTD), glutamate was applied onto dendrites of neurons in rat neocortical slices. An infrared-guided laser stimulation was used to release glutamate from caged glutamate in the focal spot df an ultraviolet laser. A burst of light flashes caused an LTD-like depression of glutamate receptor responses, which was highly confined to the region of "tetanic" stimulation (