Circadian Pattern of Plasma 17-Hydroxycorticosteroid: Alteration by Anticholinergic Agents
Circadian Pattern of Plasma 17-Hydroxycorticosteroid: Alteration by Anticholinergic Agents
复制标题
血浆 17-羟基皮质类固醇的昼夜节律模式：抗胆碱能药物的改变
DOI：
10.1126/science.155.3768.1421
复制
发表时间：
1967
期刊：
影响因子：
56.9
通讯作者：
H. P. Krieger
中科院分区：
文献类型：
--
作者：
D. Krieger;H. P. Krieger
在猫血浆中17-羟基皮质类固醇水平预期昼夜上升之前给猫注射阿托品，可以阻止这种上升。在昼夜节律的其他时间给药，阿托品不会改变这种昼夜节律模式。用短效巴比妥酸盐也观察到了与阿托品相似的结果。在预期的昼夜节律上升之前给药，并不能有效地阻止这种上升。这些发现支持这样一种假设，即血浆17-羟基皮质类固醇水平的昼夜节律模式反映了中枢神经系统在昼夜周期的关键时间段内对下丘脑-垂体-肾上腺轴的激活。
Atropine, administered to cats just prior to the time of the expected circadian rise in levels of 17-hydroxycorticosteroid in plasma, blocks this rise. Atropine does not alter this circadian pattern when administered at other times in the circadian cycle. Results similar to those obtained with atropine have been observed with short-acting barbiturates. Dibenzyline administered just prior to the time of the expected circadian rise is ineffective in blocking this rise. These findings support the hypothesis that the circadian pattern of plasma 17-hydroxycorticosteroid levels reflects activation, by the central nervous system, of the hypothalamicpituitary-adrenal axis during a "critical time period" in the circadian cycle.