BRAIN TARGET SITES FOR 1,25-DIHYDROXYVITAMIN-D3
BRAIN TARGET SITES FOR 1,25-DIHYDROXYVITAMIN-D3
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DOI：
10.1126/science.6977846
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发表时间：
1982-01-01
期刊：
影响因子：
56.9
通讯作者：
DELUCA, HF
中科院分区：
文献类型：
--
作者：
STUMPF, WE;SAR, M;DELUCA, HF
用3h标记的1,25-二羟维生素D3 [1,25(OH)2D3]放射自显影研究表明，在大鼠前脑、后脑和脊髓的某些神经元中，核保留和放射性浓度可以通过1,25(OH)2D3治疗来预防，但25-羟基维生素D3不能。除了垂体受体外，还存在脑受体，125 (OH)2D3， Ca稳态的中枢调节和该激素的其他中枢作用。假设存在脑垂体轴，用于某些1,25(OH) 2d3介导的内分泌-自主作用。
Autoradiographic studies with 3H-labeled 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] demonstrate, in certain neurons of rat forebrain, hindbrain and spinal cord, a nuclear retention and concentration of radioactivity, which can be can be prevented by treatment with 1,25(OH)2D3, but not with 25-hydroxyvitamin D3. The presence of brain receptors is indicated in addition to pituitary receptors for 1,25(OH)2D3 and a central modulation of Ca homeostasis and other central effects for this hormone are suggested. The existence of a brain-pituitary axis for certain 1,25(OH)2D3-mediated endocrine-autonomic effects is postulated.