Action of moguisteine on the activity of tracheobronchial rapidly adapting receptors in the dog.
Action of moguisteine on the activity of tracheobronchial rapidly adapting receptors in the dog.
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DOI：
10.1183/09031936.98.11020339
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发表时间：
1998-02
期刊：
影响因子：
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通讯作者：
G. Sant'ambrogio;F. Sant'ambrogio
中科院分区：
文献类型：
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作者：
G. Sant'ambrogio;F. Sant'ambrogio
本文研究了一种非麻醉性、外周作用的新型止咳药莫古司汀对气管支气管快速适应刺激受体（RARs）的作用。实验采用氨基甲酸乙酯和-氯氯蔗糖混合麻醉、胆碱麻痹、迷走神经切断和人工通气。在右迷走神经外周切端记录了单个单位动作电位，确定为起源于气管支气管RARs。这些受体的活性与食管压和动脉血压一起被记录下来。用0.4%二甲基亚砜（DMSO）或0.4%二甲基亚砜（DMSO）单独（对照品）中200微克× kg[-1]滴注的莫古斯汀刺激14只rar。在给药前（对照）和给药后2、5、10、15、20、30和45分钟记录受体活性。将每只狗2、5、10、15和20 min的结果取平均值，发现莫古斯汀使14种受体的平均活性降低至对照组的75% (p<0.05)；在给药后10-20分钟出现最大的抑制。DMSO对这些末梢的活性没有显著影响。在实验过程中，食管压、动脉压和心脏频率没有改变。总体结果表明，莫古斯汀对快速适应的刺激受体有抑制作用，这可能是该化合物抗咳嗽作用的原因。
We have studied the effects of moguisteine, a new non-narcotic, peripherally acting antitussive compound, on tracheobronchial rapidly adapting irritant receptors (RARs). Experiments were carried out on dogs anaesthetized with a mixture of urethane and alpha-chloralose, paralysed with gallamine, vagotomized and artificially ventilated. Single unit action potentials identified as originating from tracheobronchial RARs were recorded from the peripheral cut end of the right vagus nerve. The activity of these receptors was recorded together with oesophageal pressure and arterial blood pressure. Fourteen RARs were challenged with moguisteine (200 microg x kg[-1] i.v.) in 0.4% dimethylsulphoxide (DMSO) or 0.4% DMSO alone (vehicle). Receptor activity was recorded before (control) and at 2, 5, 10, 15, 20, 30 and 45 min after administration of the challenging compounds. When the results at intervals of 2, 5, 10, 15 and 20 min were averaged for each dog, it was found that moguisteine decreased the mean activity of the 14 receptors to 75% of the control value (p<0.05); the greatest inhibition occurred 10-20 min after moguisteine administration. DMSO did not significantly affect the activity of these endings. Oesophageal pressure, arterial blood pressure and cardiac frequency were not altered during the experimental procedures. The overall results indicate the presence of an inhibitory effect of moguisteine on rapidly adapting irritant receptors that could account for the antitussigenic effect of this compound.