Flexible cytokine production by macrophages and T cells in response to probiotic bacteria A possible mechanism by which probiotics exert multifunctional immune regulatory activities
Flexible cytokine production by macrophages and T cells in response to probiotic bacteria A possible mechanism by which probiotics exert multifunctional immune regulatory activities
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DOI：
10.4161/gmic.2.2.15661
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发表时间：
2011-01-01
期刊：
影响因子：
12.2
通讯作者：
Nagata, Satoru
中科院分区：
文献类型：
--
作者：
Shida, Kan;Nanno, Masanobu;Nagata, Satoru
益生菌已被报道对癌症、感染、过敏、炎症性肠道疾病和自身免疫性疾病有效，解释这些多功能活动是如何实现的很重要。干酪乳杆菌Shirota(LCS)是一种多功能益生菌，其增强宿主免疫系统的能力已被广泛研究。我们已经证明，该益生菌菌株的细胞壁结构负责有效地诱导IL-12的产生。此外，我们最近发现，LCS对Peyer‘s斑块或脾中巨噬细胞和T细胞的炎症细胞因子反应有不同的控制作用。其他研究表明，当其他细菌或其细胞成分同时存在时，LCS诱导的巨噬细胞产生的IL-12会被修改。这些发现可以为理解特定益生菌的多功能活性提供理论依据。
Probiotics have been reported to be efficacious against cancers, infections, allergies, inflammatory bowel diseases and autoimmune diseases, and it is important to explain how such multifunctional activities are realized. Lactobacillus casei Shirota (LcS) is one of these multifunctional probiotics, and its ability to augment the host immune system has been extensively examined. We have shown that the cell wall structure of this probiotic strain is responsible for potently inducing IL-12 production. In addition, we have recently found that LcS differentially controls the inflammatory cytokine responses of macrophages and T cells in either Peyer's patches or the spleen. Other studies revealed that LcS-induced IL-12 production by macrophages is modified when other bacteria or their cell components are simultaneously present. These findings can provide a theoretical basis for understanding the multifunctional activities of specific probiotics.