Extension of a new two-trial memory task in the rat: Influence of environmental context on recognition processes
Extension of a new two-trial memory task in the rat: Influence of environmental context on recognition processes
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DOI：
10.1006/nlme.1997.3746
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发表时间：
1997-03-01
影响因子：
2.7
通讯作者：
Simon, H
中科院分区：
文献类型：
--
作者：
Dellu, F;Fauchey, V;Simon, H
开发了基于Y-迷宫中的位置或物体探索的两次试验记忆任务，以研究年轻和老年Sprague-Dawley大鼠的识别过程（Dellu等人，1992年）。这种范例避免了使用可能具有非特异性影响的电击或剥夺，并且任务不需要学习规则，即，基本上涉及工作记忆。可以自动记录几只动物的许多行为参数，从而允许对几只动物的行为进行详细分析和同时测试。我们扩展了这项任务，以评估在识别记忆的上下文信息的作用。当在收购和检索试验的上下文环境是不变的，地点识别保持不变，尽管插值探索。当在获取和检索试验的上下文环境发生变化时，对象识别受损。它清楚地表明，在两个离散的线索之间的正确选择（例如，小物体）是以更分散的环境线索为条件的。因此，可以假设，至少有两种识别过程可以在动物中进行评估：一种是基于熟悉和新奇之间的区分的自动过程，另一种是基于认知和更努力的过程。总之，Y迷宫中的两次试验任务是敏感的，特异的，快速的。它允许研究空间和非空间记忆，允许研究不同水平（自动与控制）的认知过程及其神经解剖学基础，并可能有益于一般的衰老研究和神经药理学研究。(C)北京：科学出版社.
A two-trial memory task, based on place or object exploration in a Y-maze, was developed to study recognition processes in young and aged Sprague-Dawley rats (Dellu et al., 1992). This paradigm avoids the use of electric shocks or deprivations that may have nonspecific effects, and the task does not require learning of a rule, i.e., involves essentially working memory. A number of behavioral parameters in several animals could be recorded automatically, thus allowing a detailed analysis of behavior and a simultaneous testing of several animals. We extended this task in order to evaluate the role of contextual information in recognition memory. When the contextual environment during acquisition and retrieval trials was unchanged, place recognition remained intact despite interpolated explorations. When the contextual environment during acquisition and retrieval trials was changed, object recognition was impaired. It was clearly shown that the correct choice between two discrete cues (e.g., small objects) is conditional on more diffuse environmental cues. Thus, it can be hypothesized that at least two kinds of recognition processes can be assessed in animals: an automatic process, based on a discrimination between familiarity and novelty, and a second process, more cognitively based and more effortful. In conclusion, the two-trial task in the Y-maze is sensitive, specific, and fast. It allows the study of both spatial and nonspatial memory, allows the study of different levels (automatic vs controlled) of cognitive processes and their neuroanatomical substrates, and may be profitably employed in aging studies and neuropharmacological research in general. (C) 1997 Academic Press.