The carcinogen chromate induces DNA cross-links in rat liver and kidney.
The carcinogen chromate induces DNA cross-links in rat liver and kidney.
复制标题
致癌物质铬酸盐会诱导大鼠肝脏和肾脏中的 DNA 交联。
DOI：
10.1016/s0021-9258(19)69495-0
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
K. Jennette
中科院分区：
文献类型：
--
作者：
M. Tsapakos;T. Hampton;K. Jennette
从铬酸盐处理的大鼠的肝脏和肾脏中分离的细胞核中发现了DNA交联。铬酸盐暴露和总DNA交联之间的剂量依赖性关系进行了测定，使用碱性洗脱技术。肾脏DNA交联主要是DNA-蛋白质交联。铬酸盐还诱导了少量的DNA链间交联。肝细胞核除了DNA-蛋白质交联外，还含有蛋白质相关的DNA单链断裂。本文讨论了铬酸盐引起的亲器官DNA损伤与铬（VI）化合物的致癌性和毒性的关系。
DNA cross-links were found in nuclei isolated from the liver and kidney of rats treated with chromate. A dose-dependent relationship between chromate exposure and total DNA cross-links was determined using the alkaline elution technique. DNA cross-links in kidney were mainly DNA-protein in nature. Chromate also induced a small amount of interstrand DNA cross-links in kidney. Liver nuclei contained protein-associated DNA single strand breaks in addition to DNA-protein cross-links. The organotropic DNA damage induced by chromate is discussed in relation to the carcinogenicity and toxicity of chromium(VI) compounds.