Flying under the radar: TMEM106B(120-254) fibrils break out in diverse neurodegenerative disorders.
Flying under the radar: TMEM106B(120-254) fibrils break out in diverse neurodegenerative disorders.
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DOI：
10.1016/j.cell.2022.03.032
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发表时间：
2022-04-14
期刊：
影响因子：
64.5
通讯作者：
Shorter, James
中科院分区：
文献类型：
--
作者：
Copley, Katie E.;Shorter, James
神经退行性疾病通常表现出定义每种疾病的特定蛋白质的聚集。建立了TMEM 106 B（一种额颞叶变性风险因子）C-末端片段在多种神经变性疾病中意外地形成具有相似结构的淀粉样蛋白原纤维。这些未预料到的TMEM 106 B（120-254）原纤维可能预示着几种神经退行性疾病的病因转变。
Neurodegenerative diseases commonly exhibit aggregation of specific proteins that define each disease. establish that a C-terminal fragment of TMEM106B, a frontotemporal-lobar-degeneration risk factor, unexpectedly forms amyloid fibrils with similar structures in diverse neurodegenerative disorders. These unanticipated TMEM106B(120–254) fibrils may herald etiological shifts for several neurodegenerative diseases.
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