Towards a sustainable bio-based economy: Redirecting primary metabolism to new products with plant synthetic biology.
Towards a sustainable bio-based economy: Redirecting primary metabolism to new products with plant synthetic biology.
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DOI：
10.1016/j.plantsci.2018.03.012
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Shih PM
中科院分区：
文献类型：
--
作者：
Shih PM
人类已经驯化了许多植物物种，作为不可或缺的食物、材料和药物来源。合成生物学的曙光时代代表了进一步改进，重新设计和工程作物以满足各种社会和工业需求的手段。当前和未来的努力将利用植物作为生物基经济的基础，通过光合作用生产碳水化合物原料，用于生物燃料和生物产品的微生物发酵，最终目标是减少我们对石化产品的依赖。随着我们技术能力的提高，代谢工程的努力可能会通过直接生产目标化合物（包括药物、可再生燃料和商品化学品），将植物的效用扩大到糖原料之外。然而，相对较少的工作已经完成，以充分实现在植物中重定向中心碳代谢的新的生物产品的工程的潜力。虽然我们合理地设计和操纵植物代谢的能力还处于起步阶段，但我强调了将合成生物学应用于工程植物初级代谢的一些机遇和挑战。
Humans have domesticated many plant species as indispensable sources of food, materials, and medicines. The dawning era of synthetic biology represents a means to further refine, redesign, and engineer crops to meet various societal and industrial needs. Current and future endeavors will utilize plants as the foundation of a bio-based economy through the photosynthetic production of carbohydrate feedstocks for the microbial fermentation of biofuels and bioproducts, with the end goal of decreasing our dependence on petrochemicals. As our technological capabilities improve, metabolic engineering efforts may expand the utility of plants beyond sugar feedstocks through the direct production of target compounds, including pharmaceuticals, renewable fuels, and commodity chemicals. However, relatively little work has been done to fully realize the potential in redirecting central carbon metabolism in plants for the engineering of novel bioproducts. Although our ability to rationally engineer and manipulate plant metabolism is in its infancy, I highlight some of the opportunities and challenges in applying synthetic biology towards engineering plant primary metabolism.
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影响因子：
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作者：
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