Synthesis and Characterization of Biocompatible and Size-Tunable Multifunctional Porous Silica Nanoparticles
Synthesis and Characterization of Biocompatible and Size-Tunable Multifunctional Porous Silica Nanoparticles
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DOI：
10.1021/cm901259n
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发表时间：
2009-09-08
影响因子：
8.6
通讯作者：
Haynes, Christy L.
中科院分区：
文献类型：
--
作者：
Lin, Yu-Shen;Haynes, Christy L.
在这项工作中，尺寸可控的多功能介孔二氧化硅纳米粒子具有大的比表面积，嵌入发光，高磁化强度，和优良的水分散性已成功地通过使用一个简单的一锅合成。这些颗粒的尺寸和孔的顺序可以很容易地控制的基础上的二氧化硅缩合反应过程中引入的Fe 3 O 4纳米粒子成核位点的数量密度。嵌入的Fe 3 O 4纳米粒子的溶解也产生中空介孔二氧化硅纳米粒子。这些多功能的多孔纳米粒子，其特征在于通过透射电子显微镜，X-射线衍射，氮吸附-脱附行为，动态光散射，zeta电位，磁化率，和光致发光。此外，进行体外3-（4，5-二甲基噻唑-2-基）-2，5-二苯基-溴化四唑（MTT）和溶血试验，以评价任何非预期的细胞毒性。多功能纳米颗粒的生物相容性，即使在非常高的剂量下，也确保了它们在生物医学应用中的潜力。
In this work, size-controlled multifunctional mesoporous silica nanoparticles having large surface areas, embedded luminescence, high magnetization, and excellent aqueous dispersity have been successfully prepared by using a simple one-pot synthesis. The size and pore ordering of these particles can be easily controlled based on the number density of Fe3O4 nanoparticle nucleation sites introduced during the silica condensation reaction. Dissolution of the embedded Fe3O4 nanoparticles yields hollow mesoporous silica nanoparticles as well. These multifunctional porous nanoparticles were characterized by transmission electron microscopy, X-ray diffraction, nitrogen adsorption-desorption behavior, dynamic light scattering, zeta potential, magnetic susceptibility, and photoluminescence. Furthermore, in vitro 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) and hemolysis assays were performed to evaluate any unintended cytotoxicity. The biocompatibility of the multifunctional nanoparticles, even at very high doses, ensures their potential in biomedical applications.