Epidemiologic studies of group 9 pneumococci in terms of protein type and 9N versus 9V capsular type.
Epidemiologic studies of group 9 pneumococci in terms of protein type and 9N versus 9V capsular type.
复制标题
第 9 组肺炎球菌在蛋白质类型和 9N 与 9V 荚膜类型方面的流行病学研究。
DOI：
10.1093/infdis/163.4.812
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Briles,DE
中科院分区：
文献类型：
--
作者：
Waltman,WD;Gray,BM;Svanborg,C;Facklam,R;Briles,DE
用6种肺炎球菌蛋白单克隆抗体分析了荚膜9群肺炎链球菌分离株的变异性。这些抗体将104个第9组分离物区分为18种蛋白质类型，并使用抗体面板无法分型的一组（PO）。87株分离菌株的荚膜类型为9V型，9N型占70%，9A型占28%。在蛋白质类型方面，9V菌株的多样性是9N菌株的4倍。在蛋白质类型、地理来源和分离年份之间观察到显著的关联。肺炎球菌疾病的不同表现与荚膜9V型分离株的蛋白类型之间也有统计学意义的关联。因此，即使在荚膜类型内，肺炎球菌也可以高度多样化；肺炎球菌蛋白类型在流行病学研究中可用于区分环境中的相关菌株。
The variability amongStreptococcus pneumoniaeisolates of capsular group 9 was analyzed with a panel of six monoclonal antibodies to pneumococcal proteins. These antibodies differentiated the 104 group 9 isolates into 18 protein types and a group (PO) not typable with the antibody panel was used. Capsular type was determined for 87 isolates: 70% were capsular type 9V, 28% 9N, and 2% 9A. In terms of protein type, the 9V isolates were four times as diverse as the 9N isolates. Significant associations were observed between the protein type, geographic origin, and year of isolation. Statistically significant associations were also observed between different manifestations of pneumococcal disease and protein type of the capsular type 9V isolates. Thus, even within capsular types, pneumococci can be highly diverse; pneumococcal protein types may be useful in epidemiologic studies to distinguish related strains in the environment.