Sand rats see the light: Short photoperiod induces a depression-like response in a diurnal rodent
Sand rats see the light: Short photoperiod induces a depression-like response in a diurnal rodent
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DOI：
10.1016/j.bbr.2006.06.006
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发表时间：
2006-10-02
影响因子：
2.7
通讯作者：
Eilam, David
中科院分区：
文献类型：
--
作者：
Einat, Haim;Kronfeld-Schor, Noga;Eilam, David
本研究研究了模拟日长变化对昼间啮齿动物肥沙鼠（沙鼠的一种）行为的影响。动物在短光周期（5/19 光/暗周期）下饲养 3 周，并与生活在 12/12 光/暗周期下的对照组进行比较。然后，所有沙鼠都接受了强迫游泳测试，以检测抑郁样行为，并进行旷场测试，以检测整体活动。暴露于短光周期的沙鼠在游泳测试中表现出明显更早的下沉，但与对照组相比，它们的旷场活动没有差异。将这些反应视为抑郁样行为的指示，我们认为短的光周期可能会引起情感样的变化，因此沙鼠可能提供一个合适的动物模型来探索光周期对正常的、或许也可能是异常的季节性情绪变化（例如 SAD）的影响，这种情绪在人类中是一种普遍的疾病，冬季抑郁发作，春季/夏季缓解。 (c) 2006 Elsevier B.V. 保留所有权利。
The present study examined the effect of simulated change in day length on the behavior of a diurnal rodent, the fat sand rat (a species of gerbil). Animals were housed under a short photoperiod (5/19 light/dark cycle) for 3 weeks and compared with controls living under a 12/12 light/dark cycle. All sand rats then underwent the forced swim test for depression-like behavior, and the open-field test for overall activity. Sand rats exposed to the short photoperiod displayed a significantly earlier sinking in the swim test, but there was no difference between their open-field activity compared with controls. Taking these responses as indicative of depression-like behavior, we suggest that a short photoperiod may induce affective-like changes, and that the sand rat may thus offer an appropriate animal model to explore the effect of photoperiod on normal, and perhaps also abnormal, seasonal mood changes (e.g., SAD), which in humans is a prevalent disorder, with winter depression episodes and spring/summer remissions. (c) 2006 Elsevier B.V. All rights reserved.