Effects of hiking at altitude on body composition and insulin sensitivity in recovering drug addicts
Effects of hiking at altitude on body composition and insulin sensitivity in recovering drug addicts
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DOI：
10.1016/j.ypmed.2004.02.035
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发表时间：
2004-10-01
影响因子：
5.1
通讯作者：
Kuo, CH
中科院分区：
文献类型：
--
作者：
Lee, WC;Chen, JJ;Kuo, CH
在目前的研究中，有药物滥用史的个体（海洛因、可卡因或安非他明的使用者）表现出13-100%的体重增加（自我报告），并表现出胰岛素抵抗的趋势。因此，我们研究了长期高原旅行对这一特殊人群胰岛素敏感性的影响。9名男性（28.7 +/- 1.3岁）戒毒康复者和17名对照者（29 +/- 1.1岁）自愿参加了为期25天的徒步活动（海拔2200-3800 M）。在徒步旅行第25天，测量所有受试者的口服葡萄糖耐量试验（OGTT）、胰岛素反应、瘦体重、脂肪质量和腰臀比（WHR）。在高原探险后，前成瘾者在OGTT期间的胰岛素水平与对照组相似，表明这一特殊人群的胰岛素敏感性通过长期高原活动正常化。随着胰岛素敏感性的改善，WHR显著降低，但瘦体重略有增加。25天的高原活动显著逆转了前成瘾者的高胰岛素血症，这种改善似乎部分与中心脂肪的减少有关。(C) 2004癌症预防研究所和爱思唯尔公司。版权所有。
In the current study individuals with a history of drug abuse (users of heroin, cocaine, or amphetamine) displayed a 13-100% increase in body weight (self-reported) and exhibited a trend toward insulin resistance. Therefore, we investigated the effects of long-term altitude hiking on insulin sensitivity in this special population. Nine males recovering from drug addiction (ex-addicts) (age 28.7 +/- 1.3 years) and 17 control subjects (age 29 +/- 1.1 years) voluntarily participated in a 25-day hiking activity (altitude 2200-3800 M). On the 25th day of hiking, oral glucose tolerance test (OGTT), insulin response, lean body mass, fat mass, and waist-to-hip ratio (WHR) were measured in all subjects. After the altitude expedition, insulin levels during the OGTT in ex-addicts were similar to controls, suggesting that insulin sensitivity in this special population was normalized by long-term altitude activity. Along with improvements in insulin sensitivity, a significant reduction in WHR, but small increase in lean body mass, was observed. Twenty-five days of altitude activity significantly reverses hyperinsulinemia in the ex-addicts and this improvement appears to be partially associated with the reduction in central fatness. (C) 2004 The Institute For Cancer Prevention and Elsevier Inc. All rights reserved.