Spatiotemporal complexity of ventricular fibrillation revealed by tissue mass reduction in isolated swine right ventricle - Further evidence for the quasiperiodic route to chaos hypothesis
Spatiotemporal complexity of ventricular fibrillation revealed by tissue mass reduction in isolated swine right ventricle - Further evidence for the quasiperiodic route to chaos hypothesis
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DOI：
10.1172/jci119791
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发表时间：
1997-11-15
影响因子：
15.9
通讯作者：
Chen, PS
中科院分区：
文献类型：
--
作者：
Kim, YH;Garfinkel, A;Chen, PS
我们提出的证据表明心室颤动是由准周期性引起的确定性混沌。本研究的目的是确定是否可以通过组织质量的逐渐减少来产生从混沌（心室颤动，VF）到周期性（室性心动过速）的过渡，在离体和灌注猪右心室游离壁中，进行单细胞跨膜电位记录和同步标测（477个双极电极，1.6毫米分辨率），然后通过顺序切割逐渐减少组织质量，所有离体组织发生纤维颤动自发地，维持室颤的临界质量为19.9+/-4.2g，随着组织质量减少，波前数量减少，折返波前寿命增加，周期长度、舒张期间隔和动作电位持续时间延长，根据柯尔莫哥洛夫熵和庞加莱图测量，室颤的动力学复杂性平行降低。在从室颤（混沌）转变为更规则的心律失常（周期性）之前，准周期性时期变得更加明显。 总之，组织质量减少导致心室颤动波前数量的减少导致通过准周期途径从混沌动态转变为周期性动态。
We have presented evidence that ventricular fibrillation is deterministic chaos arising from quasiperiodicity. The purpose of this study was to determine whether the transition from chaos (ventricular fibrillation, VF) to periodicity (ventricular tachycardia) through quasiperiodicity could be produced by the progressive reduction of tissue mass, In isolated and perfused swine right ventricular free wall, recording of single cell transmembrane potentials and simultaneous mapping (477 bipolar electrodes, 1.6 mm resolution) were performed, The tissue mass was then progressively reduced by sequential cutting, All isolated tissues fibrillated spontaneously, The critical mass to sustain VF was 19.9 +/- 4.2 g, As tissue mass was decreased, the number of wave fronts decreased, the life-span of reentrant wave fronts increased, and the cycle length, the diastolic interval, and the duration of action potential lengthened, There was a parallel decrease in the dynamical complexity of VF as measured by Kolmogorov entropy and Poincare plots. A period of quasiperiodicity became more evident before the conversion from VF (chaos) to a more regular arrhythmia (periodicity), In conclusion, a decrease in the number of wave fronts in ventricular fibrillation by tissue mass reduction causes a transition from chaotic to periodic dynamics via the quasiperiodic route.