Dietary carotenoids contribute to normal human skin color and UV photosensitivity
Dietary carotenoids contribute to normal human skin color and UV photosensitivity
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DOI：
10.1093/jn/132.3.399
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发表时间：
2002-03-01
影响因子：
4.2
通讯作者：
Wiseman, S
中科院分区：
文献类型：
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作者：
Alaluf, S;Heinrich, U;Wiseman, S
当前研究的目的是确定饮食类胡萝卜素是否影响健康未补充的高加索（皮肤II型）受试者小组（n = 22）的皮肤色素沉着和紫外线光敏性。皮肤分光光度计和三刺激（L*a*B*）CR200色度读数在不同的身体部位进行，以分别客观地测量皮肤类胡萝卜素水平和皮肤颜色。还测量了最小暴露剂量（MED）以确定皮肤的固有UV光敏性。我们发现三色刺激B* 值（但不是L* 和a* 值）始终与包括背部在内的许多身体部位的皮肤类胡萝卜素水平密切相关。（r = 0.85，P < 0.00001）、前额（r = 0.85，P < 0.00001）、前臂内侧（r = 0.75，P < 0.0001）和手掌（r = 0.78，P < 0.0001）。皮肤类胡萝卜素水平与MED也相关（r = 0.66，P < 0.001），三刺激B* 值与MED也相关（r = 0.71，P < 0.0002）。从这些观察结果中，我们得出结论，来自正常的未补充饮食的类胡萝卜素在皮肤中积累，并赋予可测量的光保护益处（至少在浅色白种人皮肤中），这与它们在组织中的浓度直接相关。类胡萝卜素似乎也对正常人皮肤颜色有可测量的和显著的贡献，特别是如由CR 200三刺激B* 值客观定义的“黄色”的外观。基于这些研究结果，我们认为，客观的测量肤色，特别是三色刺激B* 值，可能是一个潜在的有用的手段，监测饮食中的类胡萝卜素的状态和评估的紫外线光敏性在高加索人群。
The aim of the current study was to determine whether dietary carotenoids influence skin pigmentation and UV photosensitivity in a healthy unsupplemented panel (n = 22) of Caucasian (skin Type II) subjects. Skin spectrophotometric and tristimulus (L*a*b*) CR200 chromameter readings were made at various body sites to objectively measure skin carotenoid levels and skin color, respectively. The minimal erythemal dose (MED) was also measured to determine the intrinsic UV photosensitivity of the skin. We found that tristimulus b* values (but not L* and a* values) were consistently and closely correlated with skin carotenoid levels at a number of body sites including the back (r = 0.85, P < 0.00001), forehead (r = 0.85, P < 0.00001), inner forearm (r = 0.75, P < 0.0001) and palm of the hand (r = 0.78, P < 0.0001). Skin carotenoid levels and MED were also correlated in these subjects (r = 0.66, P < 0.001), as were tristimulus b* values and MED (r = 0.71, P < 0.0002). From these observations, we conclude that carotenoids from a normal, unsupplemented diet accumulate in the skin and confer a measurable photoprotective benefit (at least in lightly pigmented Caucasian skin), that is directly linked to their concentration in the tissue. Carotenoids also appear to contribute measurably and significantly to normal human skin color, in particular the appearance of "yellowness" as defined objectively by CR200 tristimulus b* values. On the basis of these findings we believe that objective measurements of skin color, in particular tristimulus b* values, may be a potentially useful means of monitoring dietary carotenoid status and assessing UV photosensitivity in Caucasian populations.