Muonium response to low oxygen levels in haemoglobin and other biological aqueous solutions and potential application towards monitoring hypoxia
Muonium response to low oxygen levels in haemoglobin and other biological aqueous solutions and potential application towards monitoring hypoxia
复制标题
锷对血红蛋白和其他生物水溶液中低氧含量的响应以及监测缺氧的潜在应用
DOI：
10.1016/j.nima.2021.165561
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发表时间：
2021
影响因子：
1.4
通讯作者：
J. Schultz
中科院分区：
文献类型：
--
作者：
A. Pant;K. Nagamine;E. Torikai;I. Shiraki;K. Shimomura;F. Pratt;H. Ariga;K. Ishida;J. Schultz
低氧浓度或缺氧在肿瘤和癌症的诊断和治疗中起着至关重要的作用。尽管有一些现有技术，例如质子磁共振成像（MRI），可用于检测组织中的分子氧，但仍然需要新的非侵入性技术来直接测量癌组织或肿瘤组织中缺氧的程度和空间分布。在这项研究中，我们提出了一种新的非侵入性方法，使用加速器设施中可用的μ介子，例如日本的日本质子加速器研究中心和英国的卢瑟福阿普尔顿实验室。与现有的 MRI 方法不同，所提出的基于 μ 子的方法可以在没有任何外部磁场的情况下应用。借助溶液中的μ响应，我们在受控分子氧浓度下测量了各种生物材料（例如血红蛋白、白蛋白、血清和tris缓冲盐水）的水溶液中的氧浓度。通过固定氧浓度样品和氧浓度小于1%的样品观察到的μ弛豫率模式表明，该方法可用于检测人体各组织中的分子氧水平。根据我们的实验结果，我们估计了血液中血红蛋白正常生理浓度下的预期μ光谱。在设计该方法的潜在临床应用之前，需要对其他生物解决方案进行进一步的系统研究。
Low oxygen concentration or hypoxia plays a crucial role in the diagnosis and treatment of tumours and cancer. Although there are some existing techniques, such as proton magnetic resonance imaging (MRI), for the detection of molecular oxygen in tissues, new non-invasive techniques for directly measuring the extent and spatial distribution of hypoxia in cancerous or tumorous tissues are still needed. In this study, we propose a new non-invasive method using muons that are available in accelerator facilities, such as the Japan Proton Accelerator Research Complex in Japan and the Rutherford Appleton Laboratory in the UK. Unlike existing MRI methods, the proposed muon-based method can be applied without any external magnetic field. With the help of muonium response in solutions, we measured oxygen concentration in the aqueous solutions of various biological materials, such as haemoglobin, albumin, serum, and tris-buffered saline, under controlled molecular oxygen concentrations. The observed relaxation rate pattern of muonium through a fixed oxygen concentration sample and that with a sample concentration of less than 1% oxygen shows that this method may be applicable in detecting molecular oxygen levels in various tissues of the human body. Based on our experimental results, we have estimated the expected muonium spectra in normal physiological concentrations of haemoglobin in blood. Further systematic studies on other biological solutions are required before a potential clinical application of the method is devised.
影响因子：
2.7
作者：
Nagamine, K;Torikai, E
通讯作者：
Torikai, E
通过μ子自旋弛豫光谱探测人体血液中的磁性
DOI：
--
发表时间：
2005
期刊：
Proceedings of MSR-05 (In print)
影响因子：
--
作者：
K.Nagamine;K.Shimomura;K.Imai;J.Schultz;A.P.Mills.Jr
通讯作者：
A.P.Mills.Jr