Angiogenin variants are not associated with Parkinson's disease in the ethnic Chinese population
Angiogenin variants are not associated with Parkinson's disease in the ethnic Chinese population
复制标题
血管生成素变异与华裔人群中的帕金森病无关
DOI：
10.1016/j.parkreldis.2012.11.016
复制
发表时间：
2013-04-01
影响因子：
4.1
通讯作者：
Liu, Jun
中科院分区：
文献类型：
--
作者：
Liu, Bin;Zhang, Yu;Liu, Jun
最近，血管生成素基因已被报道与帕金森氏病和肌萎缩侧索硬化症的欧洲和美国血统的人口显着相关。但目前还没有研究探讨血管生成素和帕金森病之间的关联在中国人群。我们在中国大陆人群中进行了一项病例对照研究，以评估血管生成素与帕金森病之间的关联。我们对532名帕金森病患者和480名对照者的血管生成素外显子进行了测序。我们在患者和对照组中均未检测到血管生成素编码区突变。我们的数据不支持血管生成素变异与中国大陆汉族人PD的相关性。(C)2012爱思唯尔有限公司保留所有权利。
Recently, the angiogenin gene has been reported to be significantly associated with Parkinson's disease and amyotrophic lateral sclerosis in populations of European and American ancestry. But there have been no studies investigating the association between angiogenin and Parkinson's disease in the ethnic Chinese population. We conducted a case control study to evaluate the association between angiogenin and Parkinson's disease in a Chinese population from mainland China. We sequenced the exons of angiogenin in 532 Parkinson's disease patients and 480 controls. We did not detect an angiogenin coding region mutation in either the patients or the controls. Our data do not support the association of angiogenin variants with PD in Han Chinese of mainland China. (C) 2012 Elsevier Ltd. All rights reserved.