25-YEAR FOLLOW-UP-STUDY OF WOMEN EXPOSED TO DIETHYLSTILBESTROL DURING PREGNANCY
25-YEAR FOLLOW-UP-STUDY OF WOMEN EXPOSED TO DIETHYLSTILBESTROL DURING PREGNANCY
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DOI：
10.1056/nejm197804062981403
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发表时间：
1978-01-01
影响因子：
158.5
通讯作者：
HERBST, AL
中科院分区：
文献类型：
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作者：
BIBBO, M;HAENSZEL, WM;HERBST, AL
为了评估己烯雌酚的长期影响，对 693 名在怀孕期间服用该药的母亲和 668 名未服用该药的母亲进行了健康调查。这些女性参加了 1951 年至 1952 年间的一项研究，以评估该药物。 693 名暴露者中有 32 例（4.6%）患有乳腺癌，668 名未暴露者中有 21 例（3.1%）患有乳腺癌，但差异无统计学意义（P=0.16）。在任何其他类别的疾病中，各组之间没有出现统计学上的显着差异。将两组乳腺癌的发生率与 1963-1965 年康涅狄格州[美国]国家肿瘤登记处进行比较。与登记数据相比，50岁以上暴露组和未暴露组的乳腺癌发病率显着较高（P < 0.01）。这种增加的原因尚不清楚，但不能排除与参与原始临床研究的母亲选择有关的影响。
To assess the long-term effects of diethylstilbestrol a health survey was done of 693 mothers who took the drug during pregnancy and a comparable group of 668 who did not. These women participated in a study during 1951-1952 to evaluate the drug. There were 32 (4.6%) breast cancers among the 693 exposed and 21 (3.1%) among the 668 unexposed, but the difference was not statistically significant (P = 0.16). No statistically significant differences occurred between the groups in any of the other categories of disease. The occurrence of breast cancer in both groups was compared to the Connecticut [USA] State Tumor Registry for 1963-1965. Compared to the registry data, a significantly (P < 0.01) higher incidence of breast cancer occurred in exposed and unexposed groups at ages over 50. The reason for this increase is not known, but effects linked to the selection of mothers participating in the original clinical study cannot be excluded.