Electrokinetic trapping at the one nanometer limit
Electrokinetic trapping at the one nanometer limit
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DOI：
10.1073/pnas.1103554108
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发表时间：
2011-05-31
影响因子：
11.1
通讯作者：
Cohen, Adam E.
中科院分区：
文献类型：
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作者：
Fields, Alexander P.;Cohen, Adam E.
反布朗电动势阱已被用于捕获和研究大蛋白质复合物和DNA长链的自由溶液动力学。到目前为止，已经证明溶液中的小分子太过移动的而无法用任何手段捕获。在这里，我们探索捕获单个分子的极限。我们开发了一个基于反馈的反布朗电动势阱，其中经典的热噪声被补偿到量子测量噪声所允许的最大程度。我们捕获了分子量为
Anti-Brownian electrokinetic traps have been used to trap and study the free-solution dynamics of large protein complexes and long chains of DNA. Small molecules in solution have thus far proved too mobile to trap by any means. Here we explore the ultimate limits on trapping single molecules. We developed a feedback-based anti-Brownian electrokinetic trap in which classical thermal noise is compensated to the maximal extent allowed by quantum measurement noise. We trapped single fluorophores with a molecular weight of