Another case for diet restriction: TAp73-expressing medulloblastomas are stunted by glutamine withdrawal.
Another case for diet restriction: TAp73-expressing medulloblastomas are stunted by glutamine withdrawal.
复制标题
饮食限制的另一种情况：表达 TAp73 的髓母细胞瘤因谷氨酰胺戒断而发育不良。
DOI：
10.1101/gad.306837.117
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发表时间：
2017
影响因子：
10.5
通讯作者：
Flores,ElsaR
中科院分区：
文献类型：
--
作者：
Napoli,Marco;Flores,ElsaR
髓母细胞瘤是儿科人群中最常见的恶性脑癌之一，由至少四个具有独特分子和遗传特征以及临床结果的不同亚组组成。在本期《基因与发展》中，Niklison-Chirou 及其同事（第 1738-1753 页）确定 p53 家族成员和 p73 亚型 TAp73 是导致侵袭性髓母细胞瘤中谷氨酰胺成瘾的关键因素。他们的发现为使用谷氨酰胺限制作为表达 TAp73 的髓母细胞瘤的辅助治疗铺平了道路。
Medulloblastomas are among the most common malignant brain cancers in the pediatric population and consist of at least four distinct subgroups with unique molecular and genetic features and clinical outcomes. In this issue ofGenes & Development, Niklison-Chirou and colleagues (pp. 1738–1753) identify thep53family member andp73isoform TAp73 as a crucial factor causing glutamine addiction in aggressive medulloblastomas. Their findings pave the way for the use of glutamine restriction as an adjuvant treatment for TAp73-expressing medulloblastomas.