Interleukin‐15 receptor subunit alpha regulates interleukin‐15 localization and protein expression in skeletal muscle cells
Interleukin‐15 receptor subunit alpha regulates interleukin‐15 localization and protein expression in skeletal muscle cells
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DOI：
10.1113/ep090205
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发表时间：
2022-01
影响因子：
2.7
通讯作者：
Shino Yoshida;T. Fujimoto;Toshimasa Takahashi;K. Sugimoto;H. Akasaka;Minoru Tanaka;Yibin Huang
中科院分区：
文献类型：
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作者：
Shino Yoshida;T. Fujimoto;Toshimasa Takahashi;K. Sugimoto;H. Akasaka;Minoru Tanaka;Yibin Huang
这项研究的中心问题是什么？在成肌细胞分化为肌管的过程中，白细胞介素（IL）-15及其受体的动力学是如何改变的，以及IL-15是如何调节的？主要发现及其重要性是什么？IL-15和白细胞介素-2受体亚基β和γ的mRNA水平在骨骼肌分化过程中增加，而白细胞介素-15受体亚基α（IL-15 RA）表现出不同的动力学。IL-15 RA在蛋白质水平调节IL-15的定位和表达。
What is the central question of this study? How are the dynamics of interleukin (IL)‐15 and its receptors altered during the differentiation of myoblasts into myotubes, and how is IL‐15 regulated? What is the main finding and its importance? The mRNA levels of IL‐15 and interleukin‐2 receptor subunits beta and gamma increase during skeletal muscle differentiation, whereas interleukin‐15 receptor subunit alpha (IL‐15RA) exhibits different kinetics. IL‐15RA regulates the localization and expression of IL‐15 at the protein level.