The kinetics and displacement of [11C]flunitrazepam in the brain of the living baboon.
The kinetics and displacement of [11C]flunitrazepam in the brain of the living baboon.
复制标题
[11C]氟硝西泮在活体狒狒大脑中的动力学和位移。
DOI：
10.1016/0014-2999(81)90340-x
复制
发表时间：
1981
影响因子：
5
通讯作者：
R. Naquet
中科院分区：
文献类型：
--
作者：
D. Comar;M. Maziére;C. Cepeda;J. Godot;C. Menini;R. Naquet
通过正电子发射断层扫描在活狒狒体内研究[11C]氟硝西泮在大脑中的分布和动力学。氟硝西泮用 20 分钟正电子发射体碳 11 标记在甲基上。静脉注射相当于 15-30 nmol 的 15 至 25 mCi。并获得了大脑的连续断层扫描图像。在一些实验中，静脉注射治疗剂量的各种苯二氮卓类药物。随后为了研究放射性配体从大脑结构中的位移。劳拉西泮被证明可以取代脑组织中的[11C]氟硝西泮，尽管其他苯二氮卓类药物（利眠宁、Ro 116896 和 Ro 116893）会导致体内放射性配体重新分布，并伴随脑放射性增加。
The distribution and kinetics of [11C]flunitrazepam in the brain were studied by positron emission tomography in the living baboon. Flunitrazepam was labelled on the methyl group with the 20 min positron emitter carbon 11. Fifteen to 25 mCi corresponding to 15–30 nmol were injected i.v. and sequential tomographic pictures of the brain were obtained. In some experiments, therapeutic doses of various benzodiazepines were injected i.v. subsequently in order to study the displacement of the radioactive ligand from brain structures. Lorazepam was shown to displace [11C]flunitrazepam from brain tissue, although other benzodiazepines (chlordiazepoxide, Ro 116896 and Ro 116893) led to a redistribution of the radioactive ligand in the body accompanied by an increase of brain radioactivity.