Differential involvement of the central amygdala in appetitive versus aversive learning
Differential involvement of the central amygdala in appetitive versus aversive learning
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DOI：
10.1101/lm.54706
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发表时间：
2006-03-01
影响因子：
2
通讯作者：
Werka, T
中科院分区：
文献类型：
--
作者：
Knapska, E;Walasek, G;Werka, T
了解不同的杏仁核在学习中的功能是一个重大的挑战。在本文所述的两项研究中，我们使用c-Fos免疫标记来比较杏仁核的各种核团在食欲和厌恶性工具训练程序中的参与。在第一个实验中，已经获得对部分食物强化的压杆反应的大鼠被进一步训练，以了解声学刺激信号是连续食物强化（食欲训练）还是脚震（厌恶训练）。第一次训练会议的介绍声刺激导致整个杏仁核的c-Fos免疫标记显着增加，然而，激活杏仁核的模式不同，根据效价的动机。中央杏仁核的内侧部分（CE）的反应，令人惊讶的是，选择性的食欲条件反射。第二个实验的目的是扩大厌恶与食欲条件反射的小鼠，无论是在自动学习系统（INTELLICAGE）的位置偏好或位置回避训练。同样，与厌恶训练相比，食欲训练后在CE的内侧部分观察到更强烈的c-Fos表达。这些数据，在两个物种和通过新的实验方法平衡食欲与厌恶条件反射，支持的假设，中央核杏仁核是特别参与食欲动机的学习过程。
Understanding the function of the distinct amygdaloid nuclei in learning comprises a major challenge. In the two Studies described herein, we used c-Fos immunolabeling to compare the engagement of various nuclei of the amygdala in appetitive and aversive instrumental training procedures. In the first experiment, rats that had already acquired a bar-pressing response to a partial food reinforcement were further trained to learn that an acoustic Stimulus signaled either continuous food reinforcement (appetitive training) or a footshock (aversive training). The first training session of the presentation of the acoustic stimulus resulted in significant increases of c-Fos immunolabeling throughout the amygdala; however, the pattern of activation of the nuclei of the amygdala differed according to the valence of motivation. The medial part of the central amygdala (CE) responded, surprisingly, to the appetitive conditioning selectively. The second experiment was designed to extend the aversive versus appetitive conditioning to mice, trained either for place preference or place avoidance in an automated learning system (INTELLICAGE). Again, much more intense c-Fos expression was observed in the medial part of the CE after the appetitive training as compared to the aversive training. These data, obtained in two species and by means of novel experimental approaches balancing appetitive versus aversive conditioning, support the hypothesis that the central nucleus of the amygdala is particularly involved in appetitively motivated learning processes.