The future of bioactive ceramics
The future of bioactive ceramics
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DOI：
10.1007/s10856-015-5425-3
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发表时间：
2015-02-01
影响因子：
3.7
通讯作者：
Hench, Larry L.
中科院分区：
文献类型：
--
作者：
Hench, Larry L.
未来必须满足两个重要的全球需求：（1）治疗老龄化人口的健康恶化，（2）降低医疗保健成本以满足人口增长的需求。伦理和经济的困境是如何实现保健质量的平等，同时降低越来越多的人的保健成本。由第一代几乎惰性的生物材料制成的假体装置的有限寿命需要新的方法来满足这两大需求。本文建议扩大重点：（1）组织再生和（2）防止组织退化，以满足这一日益增长的需求。生物活性陶瓷的创新使用与原位组织反应的遗传控制提供了实现组织再生和预防的潜力。生物活性玻璃用于骨再生的临床成功证明了这一概念的有效性。同样地，在牙齿再矿化的牙托中使用微米尺寸的生物活性玻璃粉末提供了预防组织退化也是可能的证据。本意见书概述了在不久的将来通过生物活性玻璃和陶瓷的创新使用可以满足的临床需求;包括：骨组织再生是患者特异性的和基于遗传的，用于骨骼和韧带以及肌腱修复的承重生物活性玻璃陶瓷，软组织的修复和再生，以及对人类细胞-生物材料相互作用的快速低成本分析，导致使用分子定制的生物陶瓷进行患者特异性诊断和治疗。
Two important worldwide needs must be satisfied in the future; (1) treatment of the deteriorating health of an aging population and, (2) decreasing healthcare costs to meet the needs of an increased population. The ethical and economic dilemma is how to achieve equality in quality of care while at the same time decreasing cost of care for an ever-expanding number of people. The limited lifetime of prosthetic devices made from first-generation nearly inert biomaterials requires new approaches to meet these two large needs. This paper advises an expanded emphasis on: (1) regeneration of tissues and (2) prevention of tissue deterioration to meet this growing need. Innovative use of bioactive ceramics with genetic control of in situ tissue responses offers the potential to achieve both tissue regeneration and prevention. Clinical success of use of bioactive glass for bone regeneration is evidence that this concept works. Likewise the use of micron sized bioactive glass powders in a dentifrice for re-mineralization of teeth provides evidence that prevention of tissue deterioration is also possible. This opinion paper outlines clinical needs that could be met by innovative use of bioactive glasses and ceramics in the near future; including: regeneration of skeletal tissues that is patient specific and genetic based, load-bearing bioactive glass-ceramics for skeletal and ligament and tendon repair, repair and regeneration of soft tissues, and rapid low-cost analysis of human cell-biomaterial interactions leading to patient specific diagnoses and treatments using molecularly tailored bioceramics.