HEMOSTATIC EFFECTIVENESS OF LIQUID-PRESERVED AND PREVIOUSLY FROZEN HUMAN PLATELETS
HEMOSTATIC EFFECTIVENESS OF LIQUID-PRESERVED AND PREVIOUSLY FROZEN HUMAN PLATELETS
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DOI：
10.1056/nejm197402142900702
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发表时间：
1974-01-01
影响因子：
158.5
通讯作者：
VALERI, CR
中科院分区：
文献类型：
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作者：
VALERI, CR
为了确定不同血小板制剂的有效性，将单个单位的新鲜或保存的浓缩血小板输注给42名健康男性志愿者，并在24小时前服用650 mg阿司匹林，观察血小板存活和减少出血时间的能力。血小板在4℃保存24小时，出血时间减少1U，但存活时间较短。新鲜血小板、22°C保存24小时、-150°C含5%二甲基亚砜保存24小时均不能缩短出血时间，但具有正常寿命。用6%二甲基亚砜在-80℃保存24小时的血小板具有正常的寿命和止血效果，因此，阿司匹林对出血时间的体内影响可以被短寿命的血小板纠正，但不能被正常寿命的血小板纠正，这取决于它们的保存情况。《英国医学杂志》290：353-358,1974)
To determine the effectiveness of various platelet preparations, a single unit of fresh or preserved platelet concentrate was transfused into 42 healthy male volunteers who had been given 650 mg of aspirin 24 hours before, and platelet survival and ability to reduce bleeding time was studied.The bleeding time was reduced by 1 U of platelets stored at 4°C for 24 hours, but they had a short survival. The bleeding time was not reduced by fresh platelets, platelets stored at 22°C for 24 hours, or platelets stored with 5 per cent dimethyl sulfoxide at -150°C for 24 hours, but these platelets had normal life-span. Platelets stored with 6 per cent dimethyl sulfoxide at -80°C for 24 hours had normal life-span and hemostatic effectiveness.Thus, the in vivo effect of aspirin on bleeding time may be corrected by short-lived platelets but may not be corrected by platelets with normal life-span, depending upon their preservation. (N Engl J Med 290:353–358, 1974)