Dose Estimation for a Study of Nuclear Workers in France, the United Kingdom and the United States of America: Methods for the International Nuclear Workers Study (INWORKS).

Dose Estimation for a Study of Nuclear Workers in France, the United Kingdom and the United States of America: Methods for the International Nuclear Workers Study (INWORKS).
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DOI:
10.1667/rr14006.1
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发表时间:
2015-06
期刊:
影响因子:
3.4
通讯作者:
INWORKS Consortium
INWORKS Consortium
中科院分区:
医学3区
文献类型:
--
作者:
Thierry-Chef I;Richardson DB;Daniels RD;Gillies M;Hamra GB;Haylock R;Kesminiene A;Laurier D;Leuraud K;Moissonnier M;O'Hagan J;Schubauer-Berigan MK;Cardis E;INWORKS Consortium

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在法国、英国和美国进行的国际核工人研究 (INWORKS) 框架内,开发了更新和扩展的方法,将记录的电离辐射剂量转换为器官剂量或个人剂量当量的估计值 [Hp(10)],涉及总共 308,297 名工人,其中包括 40,035 名女性。这种方法解释了剂量计对主要工作场所能量和暴露几何形状的响应差异,以及最近发布的关于男性和女性剂量系数的 ICRP 报告。总体平均年个人剂量当量(包括零剂量)为 1.73 mSv [中位数 = 0.42;四分位距 (IQR):0.07,1.59]。估计了相关的个体器官剂量。 INWORKS 包括有可能接触中子的工人。因此,我们分析了中子剂量测定数据,以确定可能暴露于中子的工人。我们为每个工人创建了一个随时间变化的指标,根据他们是否有阳性记录的中子剂量以及如果有的话,他们的中子剂量是否曾经超过其总外部穿透辐射剂量的 10% 对他们进行分类。被标记为暴露于中子的工人人数为整个队列的 13%,其中法国为 15%,英国为 12%,美国为 14%。我们还利用体内和生物测定监测的现有信息来识别具有已知沉积物或可疑内部污染的工人。这项工作的结果是,现在可以获得允许进行各种类型的敏感性分析的信息。
In the framework of the International Nuclear Workers Study conducted in France, the UK and the U.S. (INWORKS), updated and expanded methods were developed to convert recorded doses of ionizing radiation to estimates of organ doses or individual personal dose equivalent [Hp(10)] for a total number of 308,297 workers, including 40,035 women. This approach accounts for differences in dosimeter response to predominant workplace energy and geometry of exposure and for the recently published ICRP report on dose coefficients for men and women separately. The overall mean annual individual personal dose equivalent, including zero doses, is 1.73 mSv [median = 0.42; interquartile range (IQR): 0.07, 1.59]. Associated individual organ doses were estimated. INWORKS includes workers who had potential for exposure to neutrons. Therefore, we analyzed neutron dosimetry data to identify workers potentially exposed to neutrons. We created a time-varying indicator for each worker, classifying them according to whether they had a positive recorded neutron dose and if so, whether their neutron dose ever exceeded 10% of their total external penetrating radiation dose. The number of workers flagged as being exposed to neutrons was 13% for the full cohort, with 15% of the cohort in France, 12% of the cohort in the UK and 14% in the U.S. We also used available information on in vivo and bioassay monitoring to identify workers with known depositions or suspected internal contaminations. As a result of this work, information is now available that will allow various types of sensitivity analyses.