Prevalence of Parkinson's disease in Northwestern Italy:: Comparison of tracer methodology and clinical ascertainment of cases
Prevalence of Parkinson's disease in Northwestern Italy:: Comparison of tracer methodology and clinical ascertainment of cases
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DOI：
10.1002/mds.870130305
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发表时间：
1998-05-01
影响因子：
8.6
通讯作者：
Schiffer, D
中科院分区：
文献类型：
--
作者：
Chiò, A;Magnani, C;Schiffer, D
分析了意大利西北部地区（科萨托社会卫生区，61，830名居民）的特发性帕金森病（PD）患病率，并评价了“药物示踪方法”的可靠性。通过传统的流行病学方法（全科医生，顾问神经科医生，计算机化档案）和药物示踪方法（注册左旋多巴处方）确定患者。通过对所有患者进行检查，对PD的诊断进行了临床验证。在146名接受检查的患者中，104名受PD影响，其余受其他类型的帕金森综合征影响。粗点患病率（1991年10月20日）为168/100，000人（95%置信区间[95%CI] 138-204），并逐渐增加至80-89岁年龄组。使用“示踪剂”方法，估计的粗点患病率为196（95% CI 163-235），高估了老年患者和女性的患病率，低估了年轻和受影响不太严重的病例。PD在意大利的分布不均似乎是方法因素的结果，至少部分是方法因素的结果。“示踪剂”方法学可能会导致PD流行病学特征评估的偏倚，特别是如果该方法确定的病例的临床诊断没有经过仔细验证。然而，它似乎是描述性调查的另一个案例来源。
The prevalence of idiopathic Parkinson's disease (PD) in an area of Northwestern Italy (Socio-Sanitary District of Cossato, 61,830 inhabitants) was analyzed and the reliability of "drug tracer methodology" evaluated. The patients were identified by both conventional epidemiological methodology (general practitioners, consultant neurologist, computerized archives) and drug tracer methodology (registered levodopa prescriptions). The diagnosis of PD was clinically Verified by examining all patients. Of 146 patients examined, 104 were affected by PD; the remaining by other types of parkinsonism. The crude point prevalence rate (October 20, 1991) was 168 per 100,000 population (95% confidence interval [95% CI] 138-204), with a progressive increase up to the 80-89 age group. Using "tracer'' methodology, the estimated crude point prevalence rate was 196 (95% CI 163-235), with an overestimation of the prevalence in older patients and women and an underestimation in younger and less seriously affected cases. The uneven distribution of PD in Italy appears to be the result of, at least in part, methodological factors. "Tracer" methodology may cause biases in the evaluation of the epidemiological characteristics of PD, especially if the clinical diagnosis of cases identified by this method is not carefully verified. Nevertheless, it appears useful as an additional source of cases for descriptive surveys.