Primary resetting of left atrial sensory endings in Dahl salt-sensitive rats fed a low-salt diet.
Primary resetting of left atrial sensory endings in Dahl salt-sensitive rats fed a low-salt diet.
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低盐饮食喂养的达尔盐敏感大鼠左心房感觉末梢的初步重置。
DOI：
10.1152/ajpheart.1987.253.1.h133
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Mark,AL
中科院分区：
文献类型：
--
作者：
Thoren,P;Morgan,DA;Mark,AL
迷走神经传入通路通过调节大鼠的交感神经活动，参与血管运动抑制和肾脏钠处理。在喂食低盐饮食的正常血压达尔盐敏感(S)大鼠中，低压或心肺压力感受性反射对交感神经活动的抑制被减弱。本研究的目的是记录Dahl、S和抗性(R)大鼠左心房末端迷走神经单丝的活动，以评估低压压力感受性反射减弱的机制。大鼠以低盐饮食(0.1%氯化钠)喂养5~7wk。将7只Dahl R大鼠和6只S大鼠用乌拉坦麻醉，在主动脉和左心房放置导管。单纤维记录取自右侧颈迷走神经。在分级夹闭主动脉过程中，得到左房压力与受体放电的关系。在容量扩张过程中，迷走神经传入兴奋的平均阈值S为10.4+/-0.6 mm Hg(均值+/-SE)，R大鼠为6.0+/-0.4 mm Hg(P<0.002)。S大鼠压力-放电曲线明显右移。R组和S组以增量放电/增量重叠表示的终末的最大敏感度没有显著差异，但阈值右移减少了生理充盈压力范围内的终末放电。我们还测量了清醒的S和R大鼠的左心室舒张末压力，以确定左房感觉末梢的重置是否可以用左心充盈压升高来解释。
Vagal afferent pathways contribute to vasomotor inhibition and renal sodium handling by modulating sympathetic nerve activity in rats. Low pressure or cardiopulmonary baroreflex inhibition of sympathetic nerve activity is attenuated in normotensive Dahl salt-sensitive (S) rats fed a low-salt diet. The aim of the study was to record activity in single-fiber vagal filaments from left atrial endings in Dahl S and resistant (R) rats to evaluate the mechanism for the attenuated low pressure baroreflex. Rats were fed a low-salt diet (0.1% NaCl) for 5–7 wk. Seven Dahl R and six S rats were anesthetized with urethan, and catheters were placed in the aorta and left atrium. Single-fiber recordings were obtained from the right cervical vagus. The relationship between left atrial pressure and receptor discharge was obtained during graded aortic snaring. Mean threshold for increased activation of the vagal afferents during volume expansion was 10.4 +/- 0.6 mmHg (means +/- SE) in S and 6.0 +/- 0.4 mmHg in R rats (P less than 0.002). Pressure-discharge curves were significantly shifted to the right in S rats. Maximal sensitivity of the endings expressed as delta discharge/delta LAP was not significantly different in R vs. S, but the right shift in threshold reduced the discharge of endings over a physiological range of filling pressures. We also measured left ventricular end-diastolic pressure (LVEDP) in conscious S and R rats to determine if the resetting of left atrial sensory endings could be explained by elevated left heart filling pressure.(ABSTRACT TRUNCATED AT 250 WORDS)
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