Association of XRCC1 Arg399Gln and OGG1 Ser326Cys polymorphisms with the risk of cervical cancer in Japanese subjects
Association of XRCC1 Arg399Gln and OGG1 Ser326Cys polymorphisms with the risk of cervical cancer in Japanese subjects
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DOI：
10.1016/j.ygyno.2005.05.018
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发表时间：
2005-10-01
影响因子：
4.7
通讯作者：
Hamajima, N
中科院分区：
文献类型：
--
作者：
Niwa, Y;Matsuo, K;Hamajima, N
Objective.本研究在日本进行了一项基于人群的事件病例对照研究，检测了XRCC 1 Arg 399 Gln和OGG 1 Ser 326 Cys基因多态性与宫颈癌风险的关系。方法。病例包括131例宫颈癌患者：87例鳞状细胞癌（SCC）和44例腺癌（ADC）或腺鳞癌（ADSC）。对照组为320例健康体检妇女。腺癌/腺鳞癌患者XRCC 1 399 GlnGln基因型频率高于健康对照组（OR = 2.98，95%CI = 1.11-8.01，P = 0.030）。然而，在SCC中没有证明相关性。OGG 1基因Ser 326 Cys多态性在宫颈癌组和对照组间差异无统计学意义。分层分析显示，XRCC 1399 GlnGln基因型与非吸烟者腺癌/腺鳞癌的发病风险显著增加（OR = 3.85，95%CI = 1.28-11.59，P = 0.017），但与吸烟者无关。在我们的病例中没有观察到基因间的相互作用。这是第一个报告，XRCC 1 Arg 399 Gln多态性可能是重要的，与子宫颈腺癌/腺鳞癌的风险。(c)2005年爱思唯尔公司All rights reserved.
Objective. In this study, genetic polymorphisms, XRCC1 Arg399Gln and OGG1 Ser326Cys were examined with reference to cervical cancer risk in a population-based incident case-control study in Japan.Methods. The cases comprised 131 cervical cancer patients: 87 cases with squamous cell carcinoma (SCC) and 44 with adenocarcinoma (ADC) or adenosquamous carcinoma (ADSC). Controls were sampled from 320 healthy women who underwent a health checkup.Results. The frequency of the XRCC1 399GlnGln genotype was higher in individuals with adenocarcinoma/adenosquamous carcinoma than in the healthy controls (OR = 2.98, 95% CI = 1.11-8.01, P = 0.030). However, no association was demonstrated in SCC. Analysis of OGG1 Ser326Cys polymorphism showed no significant differences between cervical cancer patients and controls. In stratification analysis, significant elevated risk of adenocarcinoma/adenosquamous carcinoma was associated with the XRCC1 399GlnGln genotype among nonsmokers (OR = 3.85, 95% Cl = 1.28-11.59, P = 0.017), but not among smokers. No gene-gene interaction was observed in our case subjects.Conclusion. This is the first report that the XRCC1 Arg399Gln polymorphism might be important in relation to the risk of adenocarcinoma/adenosquamous carcinoma of the cervix. (c) 2005 Elsevier Inc. All rights reserved.